grant
Pharmacology and toxicology of new psychoactive substances
Organization NATIONAL INSTITUTE ON DRUG ABUSELocation UNITED STATES
NIHUS FederalResearch GrantFY20253,4 methylenedioxymethamphetamine5-HT5-Hydroxytryptamine5HT5HT transporter5HTT proteinAdverse effectsAssayAutopsyBehavioral AssayBindingBioassayBioavailabilityBiological AssayBiological AvailabilityBloodBlood Reticuloendothelial SystemBlood SampleBlood specimenBody TissuesCannabinoidsCessation of lifeChromatographyClinicalCommon Rat StrainsConsciousConsciousnessDAT dopamine transporterDataDeathDetectionDopamineDrug KineticsDrugsEducationEducational aspectsEnteramineExhibitsFloridaForensic MedicineForensic SciencesForensicsGoalsHippophaineHumanHydroxytyramineIllicit DrugsIn VitroIntoxicationIsomerismK2/SpiceLaboratoriesLifeLiquid ChromatographyMDMAMarketingMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicationMedicineMethodsMethylenedioxymethamphetamineMiceMice MammalsMicrodialysisModern ManMolecular InteractionMolecular Mechanisms of ActionMolliesMurineMusN,alpha-dimethyl-1,3-benzodioxole-5-ethanamineN-Methyl-3,4-methylenedioxyamphetamineNIDANational Institute of Drug AbuseNational Institute on Drug AbuseNerve CellsNerve UnitNeural CellNeurocyteNeuronsOpiatesOpioidOutcomeOverdosePathway interactionsPharmaceutical PreparationsPharmacokineticsPharmacology and ToxicologyPhysiologic AvailabilityPublic HealthPublicationsR-Series Research ProjectsR01 MechanismR01 ProgramRatRats MammalsRattusRecreationReportingResearchResearch GrantsResearch Project GrantsResearch ProjectsResolutionRiskScheduleScientific PublicationSeriesSerotoninStimulantTabletsTestingTissuesToxicologyUniversitiesUpdateVariantVariationabuse liabilityabuse potentialabused drugabused drugsaddictionaddictive disorderanalogbath saltsbehavior studybehavioral studybiological systemsclinical relevanceclinically relevantcollegecollegiatedemethylationdopamine transporterdrug abuseddrug detectiondrug marketdrug metabolismdrug of abusedrug rewarddrug testingdrug/agentdrugs abuseddrugs of abuseecstasyextracellularhigh riskin vivointerestisomermonoaminenecropsyneuronalnovelpathwaypharmacologicpostmortemradioligandresolutionsserotonin transportersodium-dependent serotonin transportersymptomatologysynthetic cannabinoidsynthetic cathinonessynthetic drugsynthetic opiatesynthetic opioiduptake
Description preview
Substantial progress was made on this project, with the publication of five research articles reporting on the pharmacology and toxicology of opioid, cannabinoid, and stimulant NPS. In particular, there has been an increased availability of potent synthetic cathinones, like N,N-dimethylpentylone (DMP), in non-medical drug markets. DMP is a…
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