grant
Pharmacokinetic / Pharmacodynamic Optimization of ADC Therapy for Acute Myeloid Leukemia
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AML - Acute Myeloid LeukemiaAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAddressAffinityAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody FragmentsAntibody-drug conjugatesAntigensAssayBi-specific antibodiesBifunctional AntibodiesBindingBioassayBiological AssayBispecific AntibodiesBlast CellBlood PlasmaBody TissuesCD123CD123 AntigenCell BodyCell Culture TechniquesCell Surface AntigensCell membraneCellsCharacteristicsClinical EvaluationClinical TestingClinical Treatment MoabCytoplasmic MembraneDevelopmentDoseDrug DeliveryDrug Delivery SystemsDrug KineticsDrug toxicityDrugsEngineeringEnhancersEvaluationExternal DomainExtracellular DomainFutureHumanIL3RIL3RAIL3RA geneIL3RAXIL3RXImmunoglobulin FragmentsImmunological Surface MarkersIn vivo analysisInterleukin 3 Receptor AlphaInvestigational DrugsInvestigational New DrugsLeukemic progenitor and stem cellLifeLytotoxicityMalignant CellMath ModelsMedicationMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsModalityModelingModern ManMolecular InteractionMonoclonal AntibodiesMurineMusNew AgentsPatientsPatternPharmaceutical PreparationsPharmacodynamicsPharmacokineticsPharmacology and ToxicologyPlasmaPlasma MembranePlasma SerumProcessReticuloendothelial System, Serum, PlasmaSafetySiteSpecificitySurface AntigensSurface ProteinsTestingTherapeuticTherapeutic AgentsTissuesToxic effectToxicitiesVHHVHH antibodyValidationWorkacute granulocytic leukemiaacute granulocytic leukemia cellacute myeloblastic leukemia cellacute myelocytic leukemia cellacute myelogenous leukemia cellacute myeloid leukemiaacute myeloid leukemia cellacute nonlymphocytic leukemia cellarmbsAbcamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaincancer cellcell culturecell cultureschemical conjugateclinical testcomputer based predictioncytotoxiccytotoxicitydesigndesigningdevelopmentaldrug/agenteffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentshuman modelimmunogenimprovedin vivoin vivo evaluationin vivo testingleukemialeukemia stem/initiating cellsleukemic progenitorleukemic stem cellmAbsmathematic modelmathematical modelmathematical modelingmodel of animalmodel of humanmodel-based simulationmodels and simulationmonoclonal Absmouse modelmurine modelnanobodiesnanobodynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachoff-target siteoverexpressoverexpressionpatient populationpharmacodynamic modelplasmalemmapre-clinicalpreclinicalpredictive modelingpreventpreventingresearch clinical testingsafety testingsdAbsingle domain antibodiestargeted agenttreatment strategytumorvalidationsvariable heavy chain antibodyvector
Description preview
This project utilizes mechanistic pharmacokinetic / pharmacodynamic modeling to guide the development of new
therapeutic strategies, and new therapeutic agents, to improve the safety and efficacy of antibody-drug conjugate
(ADC) therapy for acute myeloid leukemia (AML). The project will generate new monoclonal antibodies and
nanobodies with…
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