grant
Phage Resistance in Emergent Vibrio cholerae and Phage Prophylaxis of Cholera
Organization TUFTS UNIVERSITY BOSTONLocation BOSTON, UNITED STATESPosted 15 May 2003Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAlimentary CanalAnimal ModelAnimal Models and Related StudiesAnimalsAntibody ResponseAntimicrobial ResistanceApplied ResearchApplied ScienceAreaBacteriaBacterial GenomeBacterial InfectionsBacteriophagesBangladeshBasic ResearchBasic ScienceCholeraClinicalCollectionDNADataDeoxyribonucleic AcidDigestive TractDiseaseDisorderDomestic RabbitDrugsEpidemicFormulationFutureGI TractGastrointestinal TractGastrointestinal tract structureGenesGenetic MaterialsGroups at riskHouseholdHumanImmune responseImmunityInfantInfectionInstructionInternationalIntestinalIntestinesLicensingLife CycleLife Cycle StagesLyticMeasuresMedicationMethodsMiceMice MammalsModelingModern ManMucosaMucosal Immune ResponsesMucosal TissueMucous MembraneMurineMusOral AdministrationOral Drug AdministrationOryctolagus cuniculusPathogenicity FactorsPatientsPeople at riskPersonsPersons at riskPhagesPharmaceutical PreparationsPlayPopulationPopulations at RiskPreventionProphylactic treatmentProphylaxisPublishingRabbitsRabbits MammalsResearch SupportResistanceResistance developmentResistance profileResistant developmentResistant profileRoleSmall IntestinesTestingTn-seqTnseqToxinTransmissionV choleraeV. choleraeVaccinesVibrio choleraeVibrio commaVirulenceVirulence FactorsVirulentVirusadulthoodage groupalimentary tractanti-microbial resistantaquatic pathogenbacteria infectionbacteria pathogenbacterial diseasebacterial pathogenbacterial virusboweldeveloping resistancediarrheal diseasediarrheal illnessdigestive canaldrug/agenteffective therapyeffective treatmentefficacy testingemerging epidemicextensive drug resistanceextensively drug resistantextreme drug resistancefitnessgenome sequencinghigh riskhost responseimmune system responseimmunoresponseindexingintraoral drug deliverylife coursemanufacturemodel of animalnew epidemicnovel epidemicpathogenpathogenic bacteriapre-clinical studypreclinical studypreventpreventingresistance mechanismresistance strainresistance to anti-microbialresistantresistant mechanismresistant strainresistant to antimicrobialsmall bowelsocial roletraittransmission processtransposon insertion sequencingtransposon sequencingvirtualwater borne pathogenwaterborne pathogen
Description preview
PROJECT SUMMARY (See instructions):
Bacteriophages (phages) are viruses that specifically kill bacteria but are safe for humans. Phages have
been shown to play important roles in the life cycle of many bacterial pathogens, particularly water-borne
pathogens that cause gastrointestinal tract infections. For example, the temperate phages, which…
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