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PFAS and bone health over the life course in Hispanic/Latinos: emerging risk factors and underlying mechanisms
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 3 Jan 2025Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY202512-20 years old21+ years oldAccelerationAddressAdolescenceAdolescentAdolescent YouthAdultAdult HumanAdverse effectsAffectAgeAnimalsAutopsyBioinformaticsBiologicalBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBone DensityBone DevelopmentBone DiseasesBone Mineral DensityBone Remodelling PathwayBone remodelingCaliforniaChemicalsChild HealthClinicalCommunitiesCountryCountyDataData ScienceDeteriorationDevelopmentDisparitiesDisparityEnvironmental ExposureEnvironmental FactorEnvironmental HealthEnvironmental Health ScienceEnvironmental Risk FactorEpidemicEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiologyEpidemiology ResearchEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationEvaluationFaceFractureHealthHigh PrevalenceHispanicHumanImpairmentIndividualInflammationIntermediary MetabolismKnowledgeLatinoLatino PopulationLatino groupLatino individualLatino peopleLatinosLifeLife CycleLife Cycle StagesLong-term cohortLongitudinal cohortMaintenanceMeasuresMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMethodologyMethodsModern ManNon-HispanicNonhispanicNot Hispanic or LatinoObesityOsteoblastsOsteoclastsOsteopeniaOsteoporosisOsteoporotic riskOutcomeOver weightOverweightPFASPathway interactionsPatternPhenotypePlasmaPlasma ProteinsPlasma SerumPoly-fluoroalkyl substancesPopulationPrevalencePreventative strategyPrevention strategyPreventive strategyProspective StudiesProteinsProteomicsResearchReticuloendothelial System, Serum, PlasmaRiskRisk FactorsSample SizeStatistical MethodsStudy of LatinosSymptomsThesaurismosisToxic effectToxicitiesTrabecular Bone ScoreVisitadiposityadolescence (12-20)adult youthadulthoodage associatedage correlatedage dependentage groupage linkedage relatedage specificagedagesbio-markersbiologicbiologic markerbiomarkerbonebone disorderbone fracturebone healthbone lossbone massbone metabolismbone preservationbone qualitybone turnoverchemical groupcohortcorpulencedata integrationdesigndesigningdevelopmentaldiabetes riskdisparities in racedisparity due to racedisparity in ethnicenvironmental riskepidemiologicepidemiologic investigationepidemiologicalepidemiology studyethnic based disparityethnic disadvantageethnic disparityethnic inequalityethnic inequityethnic subgroupethnicity disparityethnicity groupexperiencefacesfacialfragility fracturehigh dimensionalityhigh riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationinequality due to raceinequity due to raceinsightjuvenilejuvenile humanlater in lifelater lifelife courselife spanlifespanmalleable riskmetabolism disordermineralizationmodifiable risknecropsyolder adultolder adulthoodosteoporosis riskpathwayperfluorinated alkyl substancesperfluoroalkyl substancesperfluoroalkylated substancespolyfluorinated alkyl substancespolyfluoroalkyl substancespostmortemrace based disparityrace based inequalityrace based inequityrace disparityrace related disparityrace related inequalityrace related inequityracial disparityracial inequalityracial inequityracially unequalrisk developing osteoporosisrisk factor for osteoporosisskeletal tissuesocial factorsstatistic methodsyoung adultyoung adult ageyoung adulthood
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ABSTRACT
Latinos, one of the largest and fastest growing ethnic groups in the country, face a disproportionate burden of
osteoporosis, with over 40% estimated to have low bone mass. The underlying environmental factors
contributing to these disparities remain unclear. Per- and polyfluoroalkyl substances (PFAS) are ubiquitous,
persistent chemicals…
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