grant
Pesticide Use and Markers of ADRD Neurodegeneration among US Farmers
Organization HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCESLocation EAST LANSING, UNITED STATESPosted 15 Mar 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY202665 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldA β-42A β42A-beta 42A-beta42AD and related dementiaAD biological markerAD biomarkerAD related biomarkerAD related dementiaAD riskAD risk factorADRDAbeta-42Abeta42AccelerationActive Follow-upAged 65 and OverAgricultural Health StudyAgricultureAirAlzheimer risk factorAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease biological markerAlzheimer's disease biomarkerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related biomarkerAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer's related biomarkerAlzheimer’s biological markerAmentiaAmyloid beta-42Amyloid beta42Amyloid β-42Amyloid β42Amyloidβ-42Amyloidβ42AnosmiaAstroproteinAβ-42Aβ42Biological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SampleBlood specimenCategoriesCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollectionContamination in foodDataData CollectionData LinkagesDementiaDevelopmentDiagnosisDiseaseDisorderDisturbance in cognitionEnrollmentEnsureEnvironmental ExposureEnvironmental HealthEnvironmental Health ScienceEpidemiologyEventExposure AssessmentExposure toFarmFood ContaminationFoundationsGFA-ProteinGFAPGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGoalsGustationHealthHealth Insurance for Aged and Disabled, Title 18Health Insurance for Disabled Title 18HistoryHydrogen OxideImpaired cognitionInstitutionKnowledgeLinkLiteratureLongitudinal StudiesLongitudinal SurveysMT-bound tauMedicareMotorNerve DegenerationNeuron DegenerationNeuropsychologic TestsNeuropsychological TestsOccupationalOccupational ExposureOlfactionOutcomeOutcome AssessmentParalysis AgitansParkinsonParkinson DiseaseParticipantPathologyPesticidesPlasmaPlasma SerumPlayPopulationPreventative strategyPrevention strategyPreventive strategyPrimary ParkinsonismProspective cohortPublic HealthRecord Linkage StudyRecording of previous eventsResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleRuralRural PopulationRural groupRural peopleScienceSmellSmell PerceptionSoilSolidStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationSymptomsTasteTaste PerceptionTestingTimeTitle 18Waterabove age 65active followupafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardagedaged 65 and greateraged 65+aged ≥65alzheimer riskanosphrasiabio-markersbiologic markerbiomarkerbiomarker in ADbiomarker in Alzheimer'sbiomarker in Alzheimer's diseaseclinical diagnosiscognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive testingcohortcohort investigationcohort researchdementia riskdevelopmentaldisease preventiondisorder preventionenrollepidemiologicepidemiologicalexperienceexposure analysisexposure evaluationexposure measurementexposure profilingexposure surveyexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfarmerfollow upfollow-upfollowed upfollowupgustatory perceptiongustatory processinggustatory responsehealth datahealth insurance for disabledhigh riskhistorieshuman datahuman old age (65+)improvedinnovateinnovationinnovativeinsightinterestinvestigate cohortlate in lifelate lifelong-term studylongitudinal outcome studieslongitudinal research studyloss of smellmalleable riskmicrotubule bound taumicrotubule-bound taumild cognitive declinemild cognitive disordermild cognitive dysfunctionmild cognitive impairmentmild cognitive lossmild neurocognitive impairmentmodifiable riskmultidisciplinaryneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationneurotoxicneurotoxicologynovelodor perceptionolfactory lossolfactory perceptionover 65 yearspesticide exposurepre-clinicalpreclinicalprodromal ADprodromal Alzheimer'sprodromal Alzheimer's diseaseprospectivepublic health relevancerisk factor for dementiarisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk for dementiarisk of developing Alzheimer'srural individualsocial rolestatistical analysisstudy cohortsurvey cohorttaste processingtaste responsetautau Proteinstau factorworkplace exposureτ Proteins≥65 years
Description preview
Abstract
Many pesticides are neurotoxic, and high exposures may have long-term neurodegenerative consequences.
However, empirical evidence on the association between pesticides and Alzheimer’s disease and related
dementias (ADRD) is preliminary and inconsistent. This project will identify links between pesticide exposure
and markers across the…
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