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Peripheral Inflammation and Stress Drive Ventral Striatal Maladaptations
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 11 May 2023Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years old3'5'-cyclic ester of AMPAddressAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdenosine, cyclic 3',5'-(hydrogen phosphate)AdultAdult HumanAffectAffective DisordersAnxietyBasal GangliaBasal NucleiBehaviorBehavioralBiochemicalBrainBrain Nervous SystemBrain regionCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessChemical ModelsChronicClinicalCorpus StriatumCorpus striatum structureCritical PathsCritical PathwaysCyclic AMPCyclic AMP-Dependent Protein KinasesD(2) Dopamine Receptor GeneD1 receptorD2DRD2DR GeneD2RD2R GeneDRD2DRD2 geneDataDopamineDopamine D1 ReceptorDopamine Receptor D2 GeneDynorphinsDysfunctionEncephalonExposure toFemaleFiberFunctional disorderGoalsHealthHydroxytyramineImmuneImmune systemImmunesImpairmentInflammationInflammation MediatorsInflammatory Bowel DiseasesInflammatory Bowel DisorderInflammatory ResponseInterventionIntracellular Communication and SignalingKnock-outKnockoutLinkMediatingMental DepressionMental HealthMental HygieneMental disordersMental health disordersMiceMice MammalsModelingMolecularMood DisordersMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNucleus AccumbensPKAPathway interactionsPatientsPeripheralPhosphorylationPhotometryPhysiopathologyProcessProtein Kinase AProtein PhosphorylationPsychiatric DiseasePsychiatric DisorderPsychological HealthResearchRewardsRiskRisk FactorsRoleSignal PathwaySignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingStressStriate BodyStriatumStructureSubcellular ProcessSuicideSynapsesSynapticSynaptic plasticityTestingTherapeutic InterventionTransgenic OrganismsVentral StriatumVisceraladducinadenosine 3'5' monophosphateadulthoodaxon signalingaxon-glial signalingaxonal signalingbehavior responsebehavioral responsebiological adaptation to stressbiological signal transductionbrain circuitryburden of diseaseburden of illnesscAMPcAMP-Dependent Protein Kinasescell typechemical colitischemical induction of colitischemically induced colitisco-morbidco-morbiditycomorbiditydepressiondisabilitydisease burdenexperiencefatal attemptfatal suicidegastrointestinalgastrointestinal functionglia signalingglial signalingin vivoinflammatory disease of the intestineinflammatory disorder of the intestineinflammatory mediatorinhibitorinnovateinnovationinnovativeintent to dieintervention therapyintestinal autoinflammationkappa opiatekappa opioidkappa opioid receptorsmalemental illnessmortalitymultiomicsmultiple omicsnerve signalingneural signalingneurobehaviorneurobehavioralneurobiological mechanismneurochemicalneurochemistryneuronalneuronal excitabilityneuronal signalingneurophysiologicalneurophysiologyneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatryneurotransmissionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpanomicspathophysiologypathwaypharmacologicpsychiatric illnesspsychological disorderpsychological symptomreaction; crisissexsocial rolestress responsestress; reactionstressorstriatalsuicidessynapsesystemic inflammationsystemic inflammatory responsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltransgenicκ opiateκ opioidκ opioid receptorsκ-ORκOR♀♂
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PERIPHERAL INFLAMMATION AND STRESS DRIVE VENTRAL STRIATAL MALADAPTATIONS
PROJECT SUMMARY Mental illnesses such as depression and anxiety are a major disease burden linked to
suicide and mortality. It is well known that exposure to stress can precipitate neuropsychiatric complications. The
immune system also has a large influence on psychological…
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