grant
Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse Cohorts
Organization MAYO CLINIC JACKSONVILLELocation JACKSONVILLE, UNITED STATESPosted 15 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AD dementiaAddressAfrican AmericanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfro AmericanAfroamericanAlcohol DrinkingAlcohol consumptionAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's biomarkerAlzheimer's diagnosisAlzheimer's disease biological markerAlzheimer's disease diagnosisAlzheimer's disease patientAlzheimer's disease riskAlzheimer's patientAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmericanAmyloidAmyloid SubstanceAutopsyBiologicalBiological MarkersBiomedical ResearchBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SampleBlood VesselsBlood specimenBrainBrain Nervous SystemBrain VascularCaliforniaCharacteristicsClinicClinicalClinical TrialsCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCohort AnalysesCohort AnalysisCollectionCommunity OutreachDataDementiaDevelopmentDiabetes MellitusDiagnosisDiseaseDisease ProgressionDisorderDisparitiesDisparityDisturbance in cognitionEducationEducational aspectsEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtOH drinkingEtOH useEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationEvaluationExhibitsFrequenciesFundingGene variantGenesGeneticGenetic DiversityGenetic RiskGenetic VariationGenotypeGoalsHigh PrevalenceHypertensionImage data archiveImpaired cognitionIncidenceIndianaIndividualInstitutionKnowledgeLatinoLinkMT-bound tauMeasuresMethylationMichiganMolecularMolecular FingerprintingMolecular ProfilingMultiomic DataNerve DegenerationNeuron DegenerationNon-HispanicNonhispanicNot Hispanic or LatinoParticipantPathway interactionsPatternPeripheralPhenotypePlasmaPlasma SerumPopulationPreventative interventionPreventative therapyPreventive therapyPrimary Senile Degenerative DementiaPrognostic MarkerRNA SeqRNA sequencingRNAseqResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRisk-associated variantSample SizeSamplingSensitivity and SpecificitySmokingSubgroupTestingTimeTranscriptTranslationsUnderrepresented GroupsUnderrepresented PopulationsUniversitiesValidationVascular Hypertensive DiseaseVascular Hypertensive Disorderalcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakeallelic variantalzheimer riskanalyzing longitudinalbio-markersbiologicbiologic markerbiomarkercerebral vascularcerebro-vascularcerebrovascularclinical diagnosisco-morbidco-morbiditycognitive dysfunctioncognitive losscohortcomorbiditycomparativedata analysis pipelinedata archivedata archivesdata processing pipelinedementia riskdevelop therapydevelopmentaldiabetesdiagnostic biomarkerdiagnostic markerdifferential expressiondifferentially expressedendophenotypeentire genomeepigeneticallyethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol useethnic subgroupethnicity groupfull genomegene locusgenetic locusgenetic variantgenomic locationgenomic locusgenomic variantglobal gene expressionglobal transcription profilehigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimage archival systemimage archiveimage libraryimage repositoryimaging repositoryimprovedintervention designintervention developmentintervention for preventionlife-style factorlifestyle factorslongitudinal analysismethylomemicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentminimally invasivemolecular profilemolecular signaturemulti-ethnicmultiethnicmultiomicsmultiple omic datamultiple omicsnecropsynerve cell deathnerve cell lossneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneuroimagingneurological degenerationneurological imagingneuron cell deathneuron cell lossneuron deathneuron lossneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossnoveloutreach programpanomicspathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepicture archivepolygenetic risk scorespolygenic risk scorepostmortempotential biological markerpotential biomarkerprecision medicineprecision-based medicinepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprevention interventionpreventional intervention strategypreventive interventionprimary degenerative dementiaprognostic biomarkerprognostic indicatorrecruitresearch studyrisk allelerisk factor for dementiarisk for dementiarisk generisk genotyperisk locirisk locusrisk variantsample collectionsenile dementia of the Alzheimer typespecimen collectiontautau Proteinstau factortherapy designtherapy developmenttranscriptional differencestranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslationtreatment designtreatment developmenttrial readinessunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peoplevalidationsvascularwhole genomeτ Proteins
Description preview
SUMMARY
Despite a higher prevalence of Alzheimer’s disease (AD) among African Americans (AA) and Latino Americans
(LA) compared to non-Hispanic whites (NHW), these populations remain underrepresented in AD biomedical
research, particularly in biomarker studies and clinical trials. The overarching goal of Project 3 of this U19 is to
leverage…
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