grant
Peptide-conjugated phosphodiamidate morpholino oligonucleotide (PPMO)-based henipavirus therapeutics
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoVAddressAffectAnimal ModelAnimal Models and Related StudiesAnti-viral AgentsAnti-viral TherapyAntisense AgentAntisense OligonucleotidesAssayBioassayBiological AssayBody TissuesBrainBrain InflammationBrain Nervous SystemCNS Nervous SystemCOVID-19 virusCOVID19 virusCell BodyCell Culture TechniquesCellsCentral Nervous SystemClinical TrialsCoV-2CoV2CodeCoding SystemComplementary RNAConserved SequenceContainmentCricetinaeDNA mutationDataDevelopmentDiseaseDisease OutbreaksDisorderDoseDrug or chemical Tissue DistributionDucheneDuchenneDuchenne muscular dystrophyDuchenne-Griesinger syndromeEffectivenessEllis-van Creveld (EvC) syndromeEncephalitisEncephalonEquine MorbillivirusExhibitsFDA approvedFamilyFederation of MalayaFiloviridaeFilovirusGene ExpressionGene TranscriptionGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGlycine cleavage system P-proteinGlycine decarboxylaseGoalsGolden HamstersGolden Syrian HamstersHamstersHamsters MammalsHealthHendra VirusHendra henipavirusHenipavirusHumanHydrogen OxideIFNImmune EvasionIn VitroInfectionInfection preventionInitiation CodonInitiator CodonInterferon Type IInterferonsIntervening SequencesIntranasal AdministrationIntranasal Drug AdministrationIntronsLungLung ParenchymaLung Respiratory SystemLung TissueMalay FederationMalayaMalaysiaMeasles virusMesocricetus auratusMessenger RNAMiceMice MammalsModelingModern ManMurineMusMutateMutationNIAIDNasalNasal Passages NoseNational Institute of Allergy and Infectious DiseaseNeuraxisNipah VirusNipah henipavirusNoseNucleic AcidsNucleoproteinsOligoOligonucleotidesOutbreaksP-proteinPMO oligomerParamyxoviridaeParamyxovirusPathogenicity FactorsPenetrationPeptidesPhosphoproteinsPrevent infectionProductivityProteinsPseudohypertrophic Muscular DystrophyPublic HealthRNA ExpressionRNA SplicingRNA VirusesRNA chemical synthesisRNA synthesisReporterResistanceRespiratory DiseaseRespiratory Signs and SymptomsRespiratory System DiseaseRespiratory System DisorderRespiratory System, Nose, Nasal PassagesRespiratory syncytial virusRhabdoviridaeRhabdovirusesRouteSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2SingaporeSiteSplicingStart CodonStructure of parenchyma of lungSyrian HamstersTestingTherapeuticTissue DistributionTissuesToxic effectToxicitiesTranscriptionTransfectionTransgenesTranslationsTransmissionTreatment EfficacyVaccinesVero CellsViralViral ActivityViral DiseasesViral FunctionViral Gene ProductsViral Gene ProteinsViral PhysiologyViral ProteinsVirulence FactorsVirusVirus DiseasesVirus ReplicationWaterWorkWorld Health OrganizationWuhan coronavirusX-linked dilated cardiomyopathyX-linked muscular dystrophyX-linked recessive muscular dystrophyZoonosesZoonoticZoonotic Infectionairway symptomanti-viral compoundanti-viral drugsanti-viral efficacyanti-viral medicationanti-viral therapeuticanti-viralsantisense oligoaqueousbenign X-linked recessive muscular dystrophybullet shaped virus groupcell culturecell cultureschildhood pseudohypertrophic muscular dystrophyclassic X-linked recessive muscular dystrophycoronavirus disease 2019 viruscoronavirus disease-19 virusdata modelingdesigndesigningdevelopmentaleffective therapyeffective treatmentgenome mutationglycine decarboxylase P-proteinhCoV19immune evasivein vivoinhibitorintervention efficacymRNAmRNA Translationmedical countermeasuremembermild X-linked recessive muscular dystrophymodel of animalmodel of datamodel the datamodeling of the datamouse modelmurine modelnCoV2nucleaseolfactory bulboligospandemic concernpandemic potentialpandemic riskpandemic threatpathogenphosphorodiamidate morpholino oligomerpilot testpriority pathogenprogressive muscular dystrophy of childhoodprophylacticpseudohypertrophic adult muscular dystrophypseudohypertrophic muscular paralysisreplicaseresistantrespiratoryrespiratory symptomresponserougeole virusrubeola virustherapeutic candidatetherapeutic efficacytherapeutic evaluationtherapeutic testingtherapy efficacytransgenetranslationtransmission processviral RNAviral infectionviral infectious disease treatmentviral multiplicationviral replicationvirus RNAvirus infectionvirus multiplicationvirus proteinvirus-induced disease
Description preview
SUMMARY
Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus from the Henipavirus genus that causes severe
respiratory disease and encephalitis in humans. To date, no antivirals have been approved for treatment or
prevention of these infections. We will develop and test peptide-conjugated phosphorodiamidate morpholino
oligomer (PPMO)-based…
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