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PD-1 Mediated Regulation of Salivary Gland Integrity
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 1 Aug 2023Deadline 15 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025AccelerationAnimalsAsialiaAutoantibodiesAutoimmune DiseasesAutoimmune StatusAutoimmunityB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellB7-H1Biological MarkersBody TissuesCD274CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCMVCMV infectionCancersCell BodyCell Communication and SignalingCell CountCell NumberCell SignalingCellsChronicColitisCollaborationsCytomegalic Inclusion DiseaseCytomegalovirusCytomegalovirus InfectionsCytotoxic cellDataDeglutitionDenture WearDeteriorationDiseaseDisorderDry Eye SyndromesDry eye diseaseDrynessDysfunctionEsthesiaExhibitsExocrine GlandsFrequenciesFunctional disorderGeneticGlandGustationHCMVHerpesvirus 1 (beta), MuridHistopathologyHumanHyposalivationImmuneImmune Cell ActivationImmune responseImmune systemImmunesImmunologyImmunotherapeutic agentIn SituInclusion DiseaseInfectionInfiltrationInflammationInternationalIntracellular Communication and SignalingInvestigatorsK lymphocyteKO miceKeratoconjunctivitis SiccaKnock-out MiceKnockout MiceKnowledgeLaboratoriesLacrimal GlandsLacrimal deficiencyLacrimal gland structureLifeLigandsLipLip structureLong-term infectionLymphatic cellLymphocyteLymphocyticLytotoxicityMalignant NeoplasmsMalignant TumorMeasurementMeasuresMediatingMentorsModelingModern ManMolecularMouse CytomegalovirusMouth DrynessMurid herpesvirus 1Murine CytomegalovirusMusculoskeletal Pain DisorderNK CellsNK T cellNKT cellNatural Killer CellsNatural Killer T cellNull MouseOcular desiccationOrganPD 1PD-1PD-1 antibodyPD-L1PD1PD1 antibodyPDL-1PathogenesisPathologicPathologyPatientsPhysiopathologyPlayPopulationPreparationPreventionProduce salivaProductionProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1ProliferatingQOLQuality of lifeReceptor ProteinRegulationResearchResearch PersonnelResearchersRheumatic DiseasesRheumatismRheumatologic DiseasesRheumatologic DisorderRisk FactorsRoleSalivaSaliva productionSalivarySalivary Gland Virus DiseaseSalivary Gland VirusesSalivary GlandsSalivary excretionSalivary hypofunctionSalivationSelf ToleranceSensationSeroprevalencesSicca SyndromeSignal TransductionSignal Transduction SystemsSignalingSingle cell seqSjogren's DiseaseSjogren's SyndromeSjogrensSjögren SyndromeSortingSwallowingSymptomsSyndromeT-Cell ProliferationT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTasteTaste PerceptionTherapeuticTissuesTrainingViral DiseasesViral LatencyVirusVirus DiseasesVirus LatencyVitiligoWomanWorkXerostomiaXerostomicaPD-1aPD1anti programmed cell death 1anti-PD-1anti-PD-1 Abanti-PD-1 antibodiesanti-PD-1 monoclonal antibodiesanti-PD1anti-PD1 Abanti-PD1 antibodiesanti-PD1 monoclonal antibodiesanti-cancer immunotherapyanti-programmed cell death protein 1anti-programmed cell death protein 1 antibodiesanti-programmed death-1 antibodyantiPD-1anticancer immunotherapyaptyalismautoimmune antibodyautoimmune conditionautoimmune disorderautoimmune reactivityautoimmunity diseaseautoreactive antibodyautoreactivitybio-markersbiologic markerbiological signal transductionbiomarkercancer immunotherapycareercheck point blockadecheckpoint blockadechronic infectionconferenceconventioncytokinecytomegalovirus groupcytotoxicitydry eyedry mouthexperienceeye drynessglobal gene expressionglobal transcription profilegustatory perceptiongustatory processinggustatory responsehost responseimmune activationimmune check pointimmune check point blockadeimmune checkpointimmune checkpoint blockadeimmune drugsimmune system responseimmune-based cancer therapiesimmune-based therapeuticsimmune-mediated adverse eventsimmune-related adverse effectimmune-related adverse eventsimmune-related adverse reactionimmunecheckpointimmunologic therapeuticsimmunopathologyimmunoresponseimmunotherapeuticsimmunotherapy agentimmunotherapy for cancerimmunotherapy of cancerinsightirritationlymph cellmalignancymouse modelmurine modelnatural killer T lymphocyteneoplasm/cancerocular drynessocular signs of drynessocular surface drynessoral drynesspathophysiologypersistent infectionpreparationspreservationpreventpreventingprogrammed cell death 1programmed cell death ligand 1programmed cell death protein 1programmed cell death protein ligand 1programmed death 1programsprotein death-ligand 1receptorrestraintsaliva secretionsalivary gland hypofunctionsalivary productionsalivary secretionself reactive antibodysingle cell analysissingle cell next generation sequencingsingle cell sequencingskillssle2social rolesummitsymposiasymposiumsystemic lupus erythematosus susceptibility 2taste processingtaste responsetear deficiencythymus derived lymphocytetranscriptometumorviral infectionviral transmissionvirus infectionvirus transmissionvirus-induced diseasexerodermosteosisαPD-1αPD1
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Description preview
Abstract
Immune checkpoints play an important role in restraining the immune response, maintaining self-
tolerance and preventing excessive collateral damage. Immune checkpoint blockade has revolutionized cancer
immunotherapy but can lead to immune related adverse events (IrAEs). Patients receiving programmed cell
death protein 1 (PD-1) blockade…
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