grant
PBRM1 bromodomain missense mutations in ccRCC vascular signaling
Organization MEDICAL COLLEGE OF WISCONSINLocation MILWAUKEE, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAddressAffectAngiogenesis AntagonistsAngiogenesis BlockersAngiogenesis InhibitorsAngiogenesis PathwayAngiogenetic AntagonistsAngiogenetic InhibitorsAngiogenic AntagonistsAngiogenic InhibitorsAngiostatic AgentsAnti-Angiogenetic AgentsAnti-Angiogenic AgentsAnti-Angiogenic DrugsAntiangiogenesis AgentsAntiangiogenic AgentsAntiangiogenic DrugsAssayAssay for Transposase-Accessible Chromatin using sequencingBRG-1BRG-1 GeneBRG1BRG1 GeneBRM/SWI2-Related Gene-1Basal Transcription FactorBasal transcription factor genesBenignBindingBinding SitesBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBiological MarkersBiophysicsBlood Vessel TumorBlood VesselsBromodomainCancersCell Communication and SignalingCell Growth in NumberCell LineCell MultiplicationCell ProliferationCell SignalingCellLineCellular AssayCellular ProliferationCheckpoint inhibitorChromatinChromatin Remodeling ComplexChromatin Remodeling FactorClear cell renal cell carcinomaClinicalClinical TrialsCombining SiteComplexDNADNA BindingDNA Binding InteractionDNA boundDNA mutationDNA-Binding ProteinsDataData BasesDatabasesDeoxyribonucleic AcidDiseaseDisorderDrug ExposureDrugsE coliE. coliEarly DiagnosisEducationEducational aspectsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEscherichia coliFamilyFellowshipGene TargetingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsGoalsGrawitz TumorGrowthHistone AcetylationHistonesHypernephroid CarcinomaHypernephromaHypoxia Inducible FactorImmune checkpoint inhibitorIn VitroIntracellular Communication and SignalingKnowledgeL-LysineLaboratoriesLengthLinkLysineMalignant NeoplasmsMalignant TumorMediatingMedicationMissense MutationModalityMolecular Dynamics SimulationMolecular InteractionMutateMutationNeoplasms in Vascular TissueNeovascularization InhibitorsNephroid CarcinomaNon-Polyadenylated RNANuclearNuclear ProteinsNucleic AcidsOperative ProceduresOperative Surgical ProceduresOutcomeOutputPathogenesisPathway interactionsPatientsPharmaceutical PreparationsPhysiciansPredispositionProductionProteinsRNARNA ExpressionRNA Gene ProductsRNA SeqRNA sequencingRNAseqReactive SiteReaderRecombinantsRegulationRenal AdenocarcinomaRenal Cell AdenocarcinomaRenal Cell CancerRenal Cell CarcinomaReportingRibonucleic AcidRoleSMARCA4SMARCA4 geneSNF2-BetaSWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 4 GeneSaccharoseScientistSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSite-Directed MutagenesisSite-Specific MutagenesisStrains Cell LinesSucroseSurgicalSurgical InterventionsSurgical ProcedureSusceptibilityTailTargeted DNA ModificationTargeted ModificationTestingTissue GrowthToxic effectToxicitiesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTreatment-related toxicityUbiquitin Ligase Component GeneUbiquitin Ligase GeneVEGF, Hypoxia, and AngiogenesisVHL geneValidationVascular NeoplasmsVascular Tissue TumorVascular TumorVascular blood supplyalternative treatmentangiogenesisantiangiogenicassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbio-markersbiologic markerbiological signal transductionbiomarkerbiophysical foundationbiophysical principlesbiophysical sciencesblood supplyblood vessel developmentblood vessel formationblood vessel neoplasmcancer typeccRCCcell assaychromatin modificationchromatin modifiercultured cell linedata basedrug/agentearly detectionepigeneticallygene signaturesgenetic signaturegenome mutationgenome sciencesgenomic scienceimmune check point inhibitorimprovedimproved outcomein silicoinhibitorkidney adenocarcinomalenslenseslentiviral-transducedlentivirally transducedlentivirus transducedloss of functionloss of function mutationmalignancymembermissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmolecular dynamicsmutantmutational statusneglectneoplasm/cancernormoxiaontogenypathwaypatient responsepatient specific responsepolybromoprecision medicineprecision-based medicinepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreventpreventingpromoterpromotorprotein functionprotein structureprotein structuresproteins structureresponseresponsive patientside effectsocial rolestandard of caresurgerytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic toxicitytherapy associated toxicitytherapy related toxicitytherapy toxicitytranscription factortranscriptome sequencingtranscriptomic sequencingtreatment toxicitytreatment-associated toxicitytumorubiquitin ligaseunnecessary treatmentvalidationsvascularvascular supplyvon Hippel Lindau Tumor Supressor Genevon Hippel Lindau disease genevon Hippel Lindau gene
Description preview
PROJECT SUMMARY
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma. Although
outcomes are favorable with early detection and surgery, approximately 30% of patients present with
metastatic disease. This highlights the need for an improved biochemical understanding of and targeted
therapeutic options for…
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