grant
Pathogenic Mechanisms of Inflammatory Subventricular Zone Injury in Preterm Infants
NIHUS FederalResearch GrantFY2026AI analysisAcquired brain injuryAffectAgeAgonistAllelesAllelomorphsAnimal Disease ModelsAnimal Experimental UseAnimal ExperimentationAnimal ResearchB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BloodBlood Reticuloendothelial SystemBlood SampleBlood monocyteBlood specimenBrain InjuriesBreast MilkBreastmilkCausalityCell BodyCell Communication and SignalingCell DeathCell SignalingCell SurvivalCell ViabilityCellsCellular injuryCephalicChoroid PlexusCognitiveCranialCre driverDataDevelopmentDiffuseEnrollmentEpendymaEpendymal CellEpendymal TissueEpendymocyteEtiologyExtremely Low Birth Weight InfantFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryHPGFHepatocyte-Stimulating FactorHourHuman MilkHuman Mother's MilkHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinImageImmuneImmune responseImmunesImmunochemical ImmunologicImmunoglobulin Enhancer-Binding ProteinImmunologicImmunologicalImmunologicallyImmunologicsImpairmentIn VitroInfantInfiltrationInflammatoryInjuryInterleukin-6IntestinalIntestinal PerforationIntestinesIntracellular Communication and SignalingLeadLifeLinkLoxP-flanked alleleMGI-2MacrophageMacrophage ActivationMammary Gland MilkMarrow monocyteMiceMice MammalsModelingMother's MilkMotorMurineMusMyeloid Differentiation-Inducing ProteinMφNF-kBNF-kappa BNF-kappaBNFKBNecrotizing EnterocolitisNeural Stem CellNeurodevelopmental ImpairmentNeurologicNeurologicalNuclear Factor kappa BNuclear Transcription Factor NF-kBOperative ProceduresOperative Surgical ProceduresPBMCPathogenicityPatientsPb elementPerforationPeripheralPeripheral Blood Mononuclear CellPlasmacytoma Growth FactorPopulationPremature BirthPremature InfantPrematurely deliveringPreterm BirthPreterm brain injuryProductionProgenitor CellsReceptor ProteinRegulationRiskRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSourceSpontaneous intestinal perforationStructure of choroid plexusSurfaceSurgicalSurgical InterventionsSurgical ProcedureSurvivorsTestingTherapeuticTimeTranscription Factor NF-kBVentricularagesanalysis with AIanalysis with artificial intelligenceanalyzed via AIanalyzed via artificial intelligenceanimal experimentationsartificial intelligence analysisbiological signal transductionbowelbrain damagebrain damage in preterm infantsbrain injury in preterm infantsbrain-injuredcausationcell damagecell injurycellular damagedamage to cellsdevelopmentaldisease causationenrollextremely low birth weightextremely low birthweightflow cytophotometryfloxedfloxed allelegenetic approachgenetic strategyheavy metal Pbheavy metal leadhost responsehuman dataimagingimmune system responseimmunoresponsein vivoinfants born prematureinfants born prematurelyinjuriesinjury to cellsinterferon beta 2kappa B Enhancer Binding Proteinlateral ventriclematernal milkmonocytemotor impairmentmovement impairmentmovement limitationmyelinationnecrocytosisneonatal micenerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenesisneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachnuclear factor kappa betaparticipant enrollmentpatient enrollmentprematurepremature babypremature childbirthpremature deliverypremature infant humanprematuritypreterm babypreterm deliverypreterm infantpreterm infant humanpreventpreventingprogenitor and neural stem cellsprogenitor cell nicheprogenitor cell poolprogenitor cell populationprogenitor nicheprogenitor poolprogenitor populationreceptorsNuc-SeqscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell transcriptomic profilingsingle nucleus RNA-sequencingsingle nucleus seqsingle-cell RNA sequencingsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem and progenitor cell nichestem and progenitor cell populationstem cell nichestem cell poolstem cell populationstem cellssubventricular zonesurgerysystemic inflammationsystemic inflammatory responsetherapeutic evaluationtherapeutic testingtranslational opportunitiestranslational potentialultrasound
Description preview
ABSTRACT:
Preterm birth is the leading cause of life-long neurodevelopmental impairment (NDI) in infants. Common
complications of prematurity such as intestinal perforation confer a significant risk for diffuse myelination deficits
and NDI. Diffuse hypomyelination can reliably detected after affected infants reach term corrected ages however,
this…
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