grant
Pathogenic Mechanisms of ALS and Motor Neuron Diseases
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAntioncogene Protein p53ArchitectureAutoregulationBehaviorBehavioralBrainBrain Nervous SystemC-jun Amino-Terminal KinaseC-jun Kinase-1C-jun N-Terminal Kinase 1CSAID-Binding Protein 1CSAID-Binding Protein 2CSBP2CaM KIICaM PK IICaM kinase IICaMKIICalciumCalcium Ion SignalingCalcium SignalingCell Communication and SignalingCell SignalingCellular Tumor Antigen P53ComplementComplement ProteinsCytokine-Suppressive Antiinflammatory Drug-Binding Protein 1Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2DNA mutationDefectDegenerative Neurologic DisordersDevelopmentDiseaseDisease ProgressionDisorderDysfunctionEncephalonEndoplasmic ReticulumEngineering / ArchitectureErgastoplasmExtracellular Signal-Regulated Kinase GeneFunctional disorderGehrig's DiseaseGeneticGenetic ChangeGenetic defectGenetic mutationGoalsHistologicHistologicallyHomeostasisIP3RIP3R1ITPR1ITPR1 geneImaging DeviceImaging InstrumentImaging ToolImpairmentInositol 1,4,5-Triphosphate Receptor Type 1Insp3r1Intracellular Communication and SignalingInvestigationJN KinaseJNKJNK Mitogen-Activated Protein KinasesJNK1JNK1 KinaseJNK1 proteinJNK1A2JNK21B1/2KI miceKnock-in MouseKnowledgeLinkLocomotor ActivityLou Gehrig DiseaseMAP Kinase 8MAP Kinase 8 GeneMAP Kinase GeneMAPKMAPK14MAPK14 Mitogen-Activated Protein KinaseMAPK14 geneMAPK8MAPK8 Mitogen-Activated Protein KinaseMAPK8 geneMT-bound tauMediatorMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMissense MutationMitochondriaMitogen-Activated Protein Kinase 14Mitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase GeneModelingMolecularMolecular AnalysisMotor ActivityMotor CellMotor Neuron DiseaseMotor NeuronsMotor SkillsMutationMxi2Nerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronal DysfunctionNeuronsOncoprotein p53OrganellesP53PRKM8PathogenesisPathogenicityPathologicPathway interactionsPatternPhosphoprotein P53Phosphoprotein pp53PhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPopulationProtein TP53ProteinsSAP Kinase-1SAPK/JNKSAPK1 Mitogen-Activated Protein KinaseSAPK1/JNKSAPK2ASignal PathwaySignal TransductionSignal Transduction SystemsSignalingStressStress-Activated Protein Kinase 2AStress-Activated Protein Kinase JNK1Stress-Activated Protein Kinase gammaStructureSurface ProteinsTP53TP53 geneTRP53Tumor Protein p53Tumor Protein p53 GeneVesicleWorkbiological signal transductionc-jun N-Terminal Kinasecalcium-dependent CaM kinase IIcalmodulin-dependent protein kinase IIcomplementationdegenerative diseases of motor and sensory neuronsdegenerative disorder of motor neuronsdegenerative neurological diseasesdevelopmentaldisease mechanisms studyfALSfamilial ALSfamilial amyotrophic lateral sclerosisgenome mutationimaging in vivoin vivo imaginginsightjun-NH2-Terminal Kinaseknockin micemembrane structuremicrotubule bound taumicrotubule-bound taumissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmitochondrialmotoneuronmotor abilitymotor behaviormotor impairmentmotor neuron degenerationmotor neuron functionmouse modelmovement impairmentmovement limitationmurine modelmutantnerve cell deathnerve cell lossneural circuitneural circuitryneural controlneural degenerationneural dysfunctionneural regulationneurocircuitryneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuromodulationneuromodulatoryneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuroregulationp38p38 MAP Kinasep38 MAPK Genep38 Mitogen Activated Protein Kinasep38 Protein Kinasep38 SAPKp38-Alphap38Alphap53 Antigenp53 Genesp53 Tumor Suppressorpathophysiologypathwaypharmacologicpreservationprotein Bprotein p53responsestress-activated protein kinase 1synaptic circuitsynaptic circuitrysynaptobrevintautau Proteinstau factorvesicle-associated membrane proteinτ Proteins
Description preview
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive degeneration of motor neurons, including corticospinal motor neurons (CSMNs), leading to severe motor impairment. A missense mutation in vesicle-associated membrane protein–associated protein B (VAPB), P56S, is genetically linked to familial ALS and…
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