grant
Pathogenic B cell:CD4 T cell interactions in a novel B cell-dependent EAE mouse model of multiple sclerosis
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 17 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Ab responseAffectAmericanAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody FormationAntibody ProductionAntigen PresentationAntigen-Presenting CellsAntigensAutoimmuneAutopsyB blood cellsB cellB cell depletion therapyB cell differentiation factorB cell directed therapyB cell receptorB cell stimulating factor 2B cell targeted therapyB cell therapiesB cell therapyB cellsB-Cell ActivationB-Cell Antigen ReceptorB-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2B-CellsB-LymphocytesB-cellBCDFBSF-2BSF2Basal Transcription FactorBasal transcription factor genesBloodBlood Reticuloendothelial SystemBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBp35BrainBrain Nervous SystemCD183CD20CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD49d-CD29CKR-L2CMKAR3CNS DiseasesCNS disorderCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCXCR3CXCR3 geneCell BodyCell CommunicationCell InteractionCell ShapeCell-to-Cell InteractionCellsCentral Nervous System DiseasesCentral Nervous System DisordersCephalicChemokine (C-X-C Motif) Receptor 3Class II GenesClinical Treatment MoabCranialCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDataDemyelinating DiseasesDemyelinating DisordersDemyelinationsDevelopmentDiseaseDisorderDisseminated SclerosisDrugsEAEEconomic BurdenEncephalonEvaluationExhibitsExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisExternal DomainExtracellular DomainFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFolch-Lees ProteinFolch-PI Proteolipid ProteinG Protein-Coupled Receptor 9GPR9General Transcription Factor GeneGeneral Transcription FactorsHLA Class II GenesHPGFHealthHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHepatocyte-Stimulating FactorHistologicHistologicallyHomingHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-17IL-17 GeneIL-17AIL-17A GeneIL-6IL17IL17 ProteinIL17 geneIL17AIL17A GeneIL6 ProteinIP10IP10 ReceptorIP10-Mig receptorIP10-RImmuneImmunesImmunizationImmunizeInducer CellsInducer T-LymphocytesInflammationIntegrin Heterodimer alpha4beta1Integrin alpha ChainsIntegrin alpha SubunitsIntegrin alpha(4)beta(1)Integrin alpha4beta1Integrin α SubunitsIntegrin α4β1Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17Interleukin-6InvestigationInvestigatorsKineticsLesionLeu-16MGI-2MHC Class IIMHC Class II GenesMS patientMS4A1MS4A1 geneMS4A2ManuscriptsMediatingMedicationMedulla SpinalisMeningealMeningesMiceMice MammalsMig ReceptorMig-RMigRModelingModern ManMonoclonal AntibodiesMultiple SclerosisMurineMusMyelinMyelin PLPMyelin Proteolipid ProteinMyeloid Differentiation-Inducing ProteinNaturePathogenicityPathologyPathway interactionsPatientsPeptidesPeripheralPharmaceutical PreparationsPhenotypePlasmacytoma Growth FactorPlayPopulationPositionPositioning AttributePrevalenceProductionProliferatingResearch PersonnelResearchersRoleShapesSpinal CordSupporting CellSurfaceSymptomsT cell responseT-Cell ProliferationT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTimeTissuesTranscription Factor Proto-OncogeneTranscription factor genesUnited StatesVLA-4Very Late Activation Antigen-4Very Late Antigen-4VisualizationWorkaccessory cellactivated B cellsalpha Integrinsantibody biosynthesisautoimmune encephalomyelitisautoimmune reactivityautoreactivitycentral nervous system demyelinating diseasecentral nervous system demyelinating disordercytokinede-myelinating diseasesde-myelinating disordersdemyelinatedemyelinating conditionsdemyelination diseasesdemyelination disordersdevelopmentaldrug/agentearly onsetflow cytophotometryglobal gene expressionglobal transcription profilehuman modelimmunogenimmunoglobulin biosynthesisimmunoreactivityin vivoinsightinsular sclerosisinterestinterferon beta 2intra-vital imagingintravital imagingmAbsmeningemodel of animalmodel of humanmonoclonal Absmouse modelmultiple sclerosis patientmurine modelmyelin proteolipidnecropsyneural inflammationneuroinflammationneuroinflammatorynovelpathwaypatients with MSpatients with multiple sclerosispeople with Multiple sclerosispolarized cellpostmortemresponsesocial rolesuccessthymus derived lymphocytetranscription factortranscriptomeα-Integrins
Description preview
PROJECT ABSTRACT
MS is an immune-mediated demyelinating disease of the CNS, and despite first line drugs that
limit symptoms, disease progresses over time and is incurable. Given its early onset and rise in
prevalence for nearly 1 million Americans, MS presents immense health and economic burdens
on the United States. Given the success of B cell…
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