grant
Paired receptor signaling for NK cell virus control and antiviral immunity
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 12 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusAblationAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAffectAllelesAllelomorphsAssayAutologousBindingBioassayBiologic ModelsBiological AssayBiological ModelsBlocking AntibodiesBone MarrowBone Marrow Reticuloendothelial SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCITE sequencingCITE-seqCITEseqCMV infectionCRISPRCRISPR/Cas systemCell BodyCell Communication and SignalingCell SignalingCellsCellular Indexing of Transcriptomes and Epitopes by SequencingChronicClass I GenesClustered Regularly Interspaced Short Palindromic RepeatsCompetenceCytomegalic Inclusion DiseaseCytomegalovirus InfectionsCytotoxic cellDevelopmentDiseaseDisease ResistanceDisorderEducationEducational aspectsEffector CellExhibitsExposure toGenesGenetic PolymorphismHIVHIV InfectionsHLA-B57HTLV-III InfectionsHTLV-III-LAV InfectionsHealthHerpesvirus 1 (beta), MuridHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHybridsInclusion DiseaseIndividualInfectionIntracellular Communication and SignalingK lymphocyteKIR3DL1KIR3DS1KnowledgeLAV-HTLV-IIILearningLicensingLifeLigand BindingLigandsLinkLong-term infectionLymphadenopathy-Associated VirusLymphatic cellLymphocyteLymphocyticMHC Class IMHC Class I GenesMalignantMalignant - descriptorMediatingMiceMice MammalsModel SystemModelingModern ManMolecularMolecular InteractionMouse CytomegalovirusMurid herpesvirus 1MurineMurine CytomegalovirusMusNK Cell ActivationNK CellsNK cell receptor NKB1NKB1 receptorNatural Killer Cell ActivationNatural Killer CellsOutcomePathway interactionsPatientsPlayPredispositionProcessProliferatingProteomeR-Series Research ProjectsR01 MechanismR01 ProgramReceptor CellReceptor ProteinReceptor SignalingResearchResearch GrantsResearch Project GrantsResearch ProjectsResistanceResistance to infectionRiskRoleSalivary Gland Virus DiseaseSelf ToleranceSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSusceptibilityT4 CellsT4 LymphocytesTestingTherapeuticTransgenic OrganismsVariantVariationViralViral CancerViral DiseasesViral ReceptorVirusVirus DiseasesVirus ReceptorsVirus-HIVWorkanti-viral immunityantiretroviral therapyantiretroviral treatmentantiviral immunitybiological signal transductioncellular indexing of transcriptomes and epitopes by single cell sequencingchronic infectioncohortdesigndesigningdevelopmentaldisease riskdisorder riskgenetic associationimprovedinfection resistancelymph cellpathwayperipheral bloodpersistent infectionpolymorphismprogramsprotective effectpublic health relevancereceptorreceptor bindingreceptor boundresistance to diseaseresistantresistant diseaseresistant to diseaseresponsesocial roletransgene expressiontransgenicvalidation studiesviral infectionvirus infectionvirus-induced disease
Description preview
Project Summary.
Viral infections and ensuing diseases are a global threat to human life. Intriguingly, some individuals are at much
lower risk of viral infection and life-threatening disease than others, which is explained in part by host diversity.
This point is highlighted in the case of rare individuals known as `elite-controllers' who survive…
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