grant
Oxytocin-mediated calcium signaling in physiologic uterine contractility and uterine atony
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 15 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Abdominal DeliveryAddressAgonistAnimal ModelAnimal Models and Related StudiesAssayAttenuatedAwardBasic ResearchBasic ScienceBioassayBiological AssayBiologyBleedingBody TissuesC sectionCalciumCalcium Ion SignalingCalcium SignalingCaringCationsCell BodyCell Culture TechniquesCell NucleusCell membraneCellsCells Placenta-TissueCesareanCesarean sectionCessation of lifeClinical DataClinical Research ProtocolsCollagenContracting OpportunitiesContractsCytoplasmic MembraneDataDeathDevelopmentDiscipline of obstetricsDysfunctionFellowship ProgramFreezingFunctional disorderFutureGelGenerationsGenesGenetic DiversityGenetic VariationGestationGoalsHemorrhageHumanImageIn VitroInfrastructureInvoluntary MuscleKnowledgeLaboratory ResearchLeiomyocyteLinkMaternal MortalityMaternal-fetal medicineMeasuresMediatingMedicalMembraneMentorshipMiceMice MammalsModern ManModernizationMolecularMurineMusMyographyMyometrialMyometrial ContractionNormal PlacentomaNucleusObstetrical AnesthesiaObstetricsOcytocinOxytocinOxytocin ReceptorPhosphorylationPhysiciansPhysiologicPhysiologicalPhysiologyPhysiopathologyPlacentaPlacenta Embryonic TissuePlacentomePlasma MembranePositionPositioning AttributePost-partum HemorrhagePostpartum HemorrhagePregnancyPremature LaborPremature Obstetric LaborPreterm LaborPrevalenceProlonged PregnancyProphylactic treatmentProphylaxisProtein PhosphorylationReceptor ProteinRecombinant OxytocinResearchRodent ModelRoleSamplingScienceScientistShort interfering RNASingle-Nucleus SequencingSmall Interfering RNASmooth MuscleSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellTRPV channelTestingTissue SampleTissuesTrainingTranslatingTranslational ResearchTranslational ScienceUterine AtonyUterine ContractionUterine InertiaUterusVanilloidVirginiaantagonismantagonistattenuateattenuatesbiobankbiorepositoryblood losscareercell culturecell culturesclinical carecohortdevelopmentaldifferential expressiondifferentially expressedexperienceimagingin vivoinnovateinnovationinnovativeinsightknock-downknockdownmaternal deathmaternal morbiditymembrane structuremodel of animalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetobstetric careoverexpressoverexpressionpathophysiologypharmacologicplasmalemmapre-clinicalpreclinicalpreventpreventingreceptorresponsesNuc-SeqscRNA sequencingscRNA-seqsiRNAsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle nucleus RNA-sequencingsingle nucleus seqsingle-cell RNA sequencingsingle-nucleus RNA-seqskillssnRNA sequencingsnRNA-seqsocial rolestandard of caretargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptional differencestranscriptomicstransient receptor potential channel subfamily Vtransient receptor potential channel vanilloidtranslation researchtranslational investigationtranslational medicinetreatment strategyuterine contractilityuterine smooth muscle celluterine smooth muscle contractionwomb
Description preview
Project summary
Postpartum hemorrhage (PPH) is the leading global cause of maternal morbidity and mortality. Uterine atony,
insufficient uterine contractility after placental delivery, causes 80% of PPH. Oxytocin is the medical standard of
care for prophylaxis and first line treatment of PPH. However, the mechanism whereby oxytocin causes uterine…
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