grant
Oxidative Lipidomics in Pediatric Traumatic Brain Injury
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20260-11 years old15-LOX15-Lipoxygenase21+ years oldAcid-Thiol LigasesAcidsAcquired brain injuryAcuteAcyl CoA SynthetasesAcyl Coenzyme A SynthetasesAcyltransferaseAdultAdult HumanAffinityAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntioxidantsApoptoticArachidonate 15-LipoxygenaseArachidonate Omega-6 LipoxygenaseArachidonic Acid 15-LipoxygenaseArachidonic AcidsBiochemical ReactionBrainBrain InjuriesBrain Nervous SystemBrain TraumaCardiolipinsCause of DeathCell Communication and SignalingCell SignalingCephalinsCessation of lifeChildChild YouthChildhood InjuryChildren (0-21)ChronicClinical TrialsCo A LigasesCoenzyme A LigasesCoenzyme A SynthetasesCollaborationsCommon Rat StrainsComplexDataDeathEC 2.3EncephalonEndoplasmic ReticulumEnzymatic ReactionEnzyme GeneEnzymesErgastoplasmEsterificationEthanolamine PhosphoglyceridesEthanolamineglycerophospholipidsEventFamily memberFe elementFerricytochrome cFerrocytochrome cFree Radical ScavengersFree RadicalsFundingGenerationsGlutathioneH2O2HCNP Precursor ProteinHemi-MyeloperoxidaseHippocampal Cholinergic Neurostimulating Peptide PrecursorHospital AdmissionHospitalizationHydrogen PeroxideHydrolysisHydroperoxideHydroxidesImageInduction of ApoptosisInflammatory ResponseInjuryInnovative TherapyIntracellular Communication and SignalingIronLC/MSLecithinasesLinkLipid PeroxidationLipoxygenase InhibitorsLysolecithinsLysophosphatidylcholinesMechanicsMembraneMercaptansMercapto CompoundsMitochondriaMorbidityMyeloperoxidaseNCATSNational Center for Advancing Translational SciencesNational Institutes of HealthNatureNerve CellsNerve UnitNeural CellNeurocyteNeurologic outcomeNeurological outcomeNeuronsO-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)-ethanolamineOxidation-ReductionOxidative StressPathogenicityPathway interactionsPatternPeroxidasesPhosphatidesPhosphatidylethanolaminePhosphatidylethanolamine Binding ProteinPhospholipasePhospholipidsProteinsRaf Kinase Inhibitor ProteinRatRats MammalsRattusRedoxReduced GlutathioneReticulocyte Arachidonate 15-LipoxygenaseRoleScaffolding ProteinSignal TransductionSignal Transduction SystemsSignalingSourceStretchingSubstrate SpecificitySulfhydryl CompoundsSystemTBI therapyTBI treatmentTechnologyTestingTherapeuticTherapeutic UsesThiolsTranslationsTraumaTraumatic Brain InjuryUnited States National Institutes of HealthWorkadductadulthoodapoptosis of neuronal cellsbaicaleinbiological signal transductionbrain damagebrain-injuredcatalystcognitive functioncontrolled cortical impactcytochrome cdesigndesigningdrug discoveryexperimentexperimental researchexperimental studyexperimentsgamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycineglutathione peroxidaseimagingimproved outcomeinhibitorinjured childinjured childreninjuriesinjury in childrenkidslipidomicsliquid chromatography mass spectrometrymechanicmechanicalmembrane structuremitochondrialmortalitynerve cell deathnerve cell lossneuron apoptosisneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal apoptosisneuronal cell deathneuronal cell lossneuronal cells programmed cell deathneuronal deathneuronal lossneurons programmed cell deathneuroprotectionneuroprotectivenew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetoxidationoxidation reduction reactionpathwaypediatric TBIpediatric injurypediatric traumatic brain injuryperoxidationpostnatalpreferencepreservationpreventpreventingprogrammed cell death of neuronal cells by apoptosisprogrammed cell death of neurons by apoptosisprotein complexsmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolespatial and temporalspatial temporalspatiotemporalstandard carestandard treatmentsulfhydryl grouptargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthiokinasetranslationtraumatic brain damagetraumatic brain injury therapytraumatic brain injury treatmentyoungster
Description preview
Each year in the US, severe TBI in children results in ∼7400 deaths and 60 000 hospitalizations. Fifty percent
of surviving children with severe TBI have poor neurological outcome at six months. Severe TBI in children is
thus a critical problem in desperate need of impactful therapies. Free radicals and oxidative stress have been
uniformly…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click