grant
Overcoming innate drug efflux systems to expand anthelmintic vulnerability
Organization IOWA STATE UNIVERSITYLocation AMES, UNITED STATESPosted 13 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202621+ years oldABC Transport ProteinABC Transporter ProteinABC TransportersABC20ABCB1ABCB1 geneATP-Binding Cassette TransportersAddressAdultAdult HumanAmino AcidsAnthelminticsAntihelminthic AgentAntihelminthic DrugsAntiparasitic AgentsAntiparasitic DrugsAntiparasiticsAscarisBindingBlood - brain barrier anatomyBlood-Brain BarrierCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell IsolationCell LineCell SegregationCell SeparationCell Separation TechnologyCellLineCellsCessation of lifeClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollectionCommunicable DiseasesCytometryDeathDefense MechanismsDiseaseDisorderDrug EffluxDrugsEukaryotic CellExhibitsFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFaceFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsFutureGP170GeneHomologGenesGlycoproteinsGoalsHemato-Encephalic BarrierHomologHomologous GeneHomologueHumanImage CytometryImpoverishedIndividualInfectious DiseasesInfectious DisorderIntestinalIntestinesInvestigatorsKidneyKidney Urinary SystemKnock-outKnockoutKnowledgeLarvaLeadLibrariesLicensingLife CycleLife Cycle StagesLiverMDR-1MDR1MDR1 ProteinMammaliaMammalsMarketingMeasuresMediatingMedicationMessenger RNAMissionModern ManMolecular InteractionMolecular TargetMultidrug Resistance 1Multidrug Resistance Gene-1Multidrug Resistance Gene-1sMultidrug Resistance ProteinsMultidrug Resistant ProteinsNational Institutes of HealthNatureNematodaNematodesOutcomeP-GPP-GlycoproteinP-Glycoprotein 1 GenePGY-1 ProteinPGY1ParasitesParasitic nematodeParasiticidesPb elementPharmaceutical PreparationsPharmacological StudyPharmacologyPharmacology StudyPhenotypePhysiologyPopulationPovertyPropertyRNA SeqRNA sequencingRNAseqResearch PersonnelResearchersRestScientistStrains Cell LinesSystemTechniquesToxinUnited States National Institutes of HealthVermifugesXenobioticsadulthoodaminoacidantihelminthicbloodbrain barrierbowelcell sortingcultured cell linedevelop drug resistancedisease controldisorder controldrug resistance developmentdrug/agentefflux pumpfacesfacialfrontierglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadhepatic body systemhepatic organ systemimprovedinhibitorinnovateinnovationinnovativelife courselong read seqlong-read sequencinglong-read transcript sequencingmRNAmutantneglectnew drug classnovelnovel drug classparasitic roundwormpreventpreventingpsychological defense mechanismrenalrestorationroundwormsealsmall moleculetooltranscriptometranscriptome sequencingtranscriptomic sequencing
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Project Summary
Nematode parasites are present nearly every place in the world inhabited by humans. Our
strategy for controlling these diseases is to use small molecule therapy, however, there has not
been a new drug class on the market in 40 years. We propose that endogenous transporter
systems of parasites are innate, dynamic, and play a role in…
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