grant
Outer sphere tuning of a Eu(II)-containing contrast agent for imaging hypoxia via MRI
Organization WAYNE STATE UNIVERSITYLocation DETROIT, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2026AbscissionAddressAffectAreaBody TissuesCO2Carbon DioxideCarbonic AnhydrideCell Communication and SignalingCell NucleusCell RespirationCell SignalingCellular RespirationCharacteristicsChemical Shift ImagingChemicalsClinicalComplexContrast AgentContrast DrugsContrast MediaCreativenessDiagnosticDiffusionDiseaseDisorderEnsureEnvironmentEu elementEuropiumExcisionExposure toExtirpationF elementFluorineFluorocarbonsGasesGoalsHalf-LifeHealthHypoxiaHypoxicImageImage EnhancementIn VitroInjectionsInterventionIntracellular Communication and SignalingIonsKineticsKnowledgeLawsLigandsLocationMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMaintenanceMapsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicineMethodsMissionModalityNMR ImagingNMR TomographyNational Institutes of HealthNuclear Magnetic Resonance ImagingNucleusO elementO2 elementO2 imagingO2 mappingOutcomeOxidation-ReductionOxygenOxygen DeficiencyPerfluorocarbonsPerfusionPhysiologicPhysiologicalPlayPropertyProxyPublic HealthRadiopaque MediaRedoxRemovalReportingResearchResistanceRoleSignal TransductionSignal Transduction SystemsSignalingSiteSolubilitySpectroscopySpectrum AnalysesSpectrum AnalysisSurfaceSurgical RemovalSystemTestingTherapeuticTimeTissuesUnited States National Institutes of HealthVisualizationZeugmatographyaerobic metabolismaerobic respirationbiocompatibilitybiological signal transductionbiomaterial compatibilitycontrast enhancedcreativitydiffuseddiffusesdiffusingdiffusionsexperimentexperimental researchexperimental studyexperimentshuman diseaseimage-based methodimagingimaging agentimaging approachimaging based approachimaging methodimaging modalityimprovedin vivoinnovateinnovationinnovativeinterestnano emulsionnano particlenano-sized particlenanoemulsionnanoparticlenanosized particleoptoacoustic imagingoxidationoxidation reduction reactionoxidative metabolismoxygen imagingoxygen mappingoxygen pressure imagingoxygen pressure mappingoxygenation imagingoxygenation mappingphotoacoustic imagingpre-clinicalpreclinicalpressurepreventpreventingprognosticratiometricresectionresistantsocial roletumorweighted imaging
Description preview
Project Abstract
The ability to image oxygen in vivo has important diagnostic, prognostic, and therapeutic implications because
hypoxia is correlated with aggressive disease states and resistance to many types of treatments. EuII/III-based
systems for magnetic resonance imaging (MRI) are an attractive approach for imaging hypoxia due to their…
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