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Osteoclasts or RANKL: Which is the critical target in treatment of fibrous dysplasia bone lesions?
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025ActinsAffectAlternative TherapiesAlternative interventionAnatomic AbnormalityAnatomical AbnormalityAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody TherapyAutomobile DrivingBindingBiological FunctionBiological ProcessBiologyBisphosphonatesBlocking AntibodiesBody Temperature RegulationBody ThermoregulationBody TissuesBone 4-Carboxyglutamic ProteinBone Formation InhibitionBone Gla ProteinBone ResorptionBone gamma-Carboxyglutamic Acid ProteinBone remodelingBreast Epithelial CellsBundle BoneCD115CD115 GeneCSF1CSF1 geneCSF1RCSF1R geneCSFMRCell BodyCell Communication and SignalingCell LineageCell SignalingCellsColony Stimulating Factor 1 Receptor GeneCouplingCytokine ReceptorsDNA mutationDataDeformityDevelopmentEnvironmentFibrosisFibrous DysplasiaFibrous Dysplasia of BoneFractureGene TranscriptionGeneralized GrowthGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsGrowthHematopoieticHumanImmature BoneImmunoglobulin Enhancer-Binding ProteinIndividualInhibition of Cell ProliferationIntestinalIntestinesIntracellular Communication and SignalingInvestigationInvoluntary MuscleIschemic StrokeJaffe-Lichtenstein syndromeLesionLigandsLineage TracingLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesM cellMCSFMGC31930MarrowMiceMice MammalsModelingModern ManMolecularMolecular InteractionMurineMusMutationNF-kBNF-kappa BNF-kappaBNFKBNegative Control of Cell ProliferationNegative Regulation of Cell ProliferationNonlamellar BoneNuclear Factor kappa BNuclear Transcription Factor NF-kBOsteitis Fibrosa DisseminataOsteoblastsOsteocalcinOsteoclastic Bone LossOsteoclastsPainPainfulPathogenesisPathologicPathway interactionsPatientsPhenotypePhysiologic ThermoregulationPositionPositioning AttributePredispositionProliferatingRNA ExpressionReceptor InhibitionReceptor ProteinRoleSignal TransductionSignal Transduction SystemsSignalingSmooth MuscleSpecialized Epithelial CellSusceptibilityTestingThermoregulationThymic epithelial cellTissue GrowthTissuesTranscriptionTranscription Factor NF-kBVitamin K-Dependent Bone ProteinVitamin K-Dependent Calcium-Binding ProteinWithdrawalWoven Boneantibody based therapiesantibody treatmentantibody-based therapeuticsantibody-based treatmentbiological signal transductionbiphosphonatebisphosphonatebonebone erosionbone fracturebone turnoverbowelc-FMSc-fms Genesc-fms Proto-Oncogenescell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingcomparable efficacycomparative efficacycompare efficacycompare treatmentcytokinedevelopmentaldigitaldiphosphonatedrivingeffective therapyeffective treatmentexperienceexperimentexperimental researchexperimental studyexperimentsgenome mutationhemopoieticimprovedinhibiting antibodyinsulin sensitivitykappa B Enhancer Binding Proteinlymph glandlymph nodeslymphnodesmammary epithelial cellsmammary gland epithelial cellsmodel of animalmosaicmouse modelmurine modelmutantneuroprotectionneuroprotectiveneutralizing antibodynuclear factor kappa betaontogenyosteoblast cell differentiationosteoblast differentiationosteoblastic differentiationosteoclastogenesispathwayphase 2 studyphase II studypostnatalpre-clinicalpreclinicalpreventpreventingreceptorresponsesarcopeniasarcopenicside effectskeletalskeletal progenitorskeletal progenitor cellskeletal stem cellsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettreatment comparison
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Description preview
Project Summary
Fibrous dysplasia (FD) affects approximately 1 in 5000 individuals and causes focal bone lesions that result in
pain, deformity and fracture susceptibility. FD lesions are characterized by an accumulation of immature
osteoblast lineage cells as well as robust osteoclastogenesis with increased bone turnover. Receptor activator
of…
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