grant
Osmotic regulation in the cone dystrophy, CDSRR
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20260-11 years old2-amino-ethanesulfonic acidAbscissionAdolescentAdolescent YouthAtrophicAtrophyAutoregulationBest DiseaseBlindnessCausalityCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChaperoneChildChild YouthChildhoodChildren (0-21)ChronicConeCone PhotoreceptorsCone dystrophyDNA TherapyDNA mutationDarknessDataDevelopmentDiseaseDisorderDoppler OCTDysfunctionEmotionalEmotionsEnergy-Linked TranshydrogenaseEnzyme GeneEnzymesEtiologyExcisionExtirpationFailureFamilial juvenile macular degeneration syndromeFluid BalanceFluid HomeostasisFunctional disorderGaussian DistributionGene ExpressionGene TranscriptionGene Transfer ClinicalGenesGenetic ChangeGenetic InterventionGenetic TranscriptionGenetic defectGenetic mutationGoalsHealth CareHereditaryHereditary DiseaseHomeostasisHydrationHydration statusHydrogen OxideImageInborn Genetic DiseasesInheritedInherited disorderIntermediary MetabolismIntracellular Communication and SignalingIon ChannelIonic ChannelsIonsJuvenile RetinoschisisJuvenile onset macular degenerationK channelK elementKO miceKnock-out MiceKnockout MiceKnowledgeLightMacular degenerationMacular degenerative diseaseMaintenanceMeasuresMediatingMembraneMembrane ChannelsMetabolicMetabolic ProcessesMetabolismMethodsMiceMice MammalsMitochondriaMitochondrial TranshydrogenaseMolecularMolecular ChaperonesMuller gliaMuller's cellMurineMusMutationMüller cellMüller gliaNAD TranshydrogenaseNAD(P)+ transhydrogenaseNADP TranshydrogenaseNADPH NAD TranshydrogenaseNADPH TransferaseNicotinamide Nucleotide TranshydrogenaseNormal DistributionNormal Statistical DistributionNull MouseNutrientOCT TomographyOptical Coherence TomographyOsmosisOutcomeOuter pigmented layer of retinaPersonsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiological HomeostasisPhysiopathologyPigment cell layer of retinaPigmented layer of retinaPotassiumPotassium ChannelPotassium Ion ChannelsProcessProductionPyridine Nucleotide TranshydrogenaseRNA ExpressionReadingRecyclingRegulationRemovalResearchRespirationRetinaRetinal ConeRetinal DegenerationRetinal DiseasesRetinal DisorderRetinal Pigment EpitheliumRetinal pigment epithelial cellsRetinoschisis, Juvenile, X Chromosome-LinkedRetinoschisis, Juvenile, X-LinkedRodRods and ConesSTGD3STGD3 diseaseSightSignal TransductionSignal Transduction SystemsSignalingStargardt diseaseStargardt macular dystrophyStargardt syndromeStargardt's diseaseStargardt-3Stargardt-3 macular dystrophyStargardt-like macular dystrophyStressStructure of retinal pigment epitheliumSubcellular ProcessSurgical RemovalSwellingTauphonTaurineTeenTeenagersTestingTextTranscriptionTranshydrogenaseVertebrate PhotoreceptorsVisionVisual ReceptorVitamin AVitelliform MDVitelliform macular dystrophyVoltage-Gated K+ ChannelsVoltage-Gated Potassium ChannelWaterWater MovementsWorkX-Linked Retinoschisisbest macular dystrophybiological signal transductioncausationcone celldegenerative retina diseasesdevelopmentaldisease causationearly adulthoodearly childhoodemerging adultfundus flavimaculatusgene repair therapygene therapygene-based therapygenetic therapygenome mutationgenomic therapyhereditary disorderheritable disorderimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedin vivoinborn errorinherited diseasesinherited genetic diseaseinherited genetic disorderinhibitorjuvenilejuvenile humankidsmaculamacularmacular dystrophymembrane structuremitochondrialmouse modelmurine modelnoveloptical Doppler tomographyoptical coherence Doppler tomographypathophysiologypatient responsepatient specific responsepediatricphotoreceptor degenerationpreservationresectionrespiratory mechanismresponseresponsive patientretina degenerationretina diseaseretina disorderretinal degenerativeretinal degenerative diseasesretinopathyscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstemteen yearsteenagetranscriptomicstreatment strategyvision lossvisual functionvisual lossyoungster
Description preview
Project Summary
Vision is our primary sense. We rely on vision for everything from building our sense of reality,
to navigating obstacles, identifying threats, and reading text and emotions. Untreatable vision
loss beginning in childhood is often emotionally devastating and incurs a lifetime of healthcare
expenses. This is the situation for people…
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