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Oseltamivir Use and Risk of Serious Neuropsychiatric Adverse Events in Children
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Mar 2022Deadline 28 Feb 2026 β οΈ
NIHUS FederalResearch GrantFY20250-11 years old4-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidABC20ABCB1ABCB1 geneActive LearningAddressAdverse ExperienceAdverse drug eventAdverse effectsAdverse eventAlgorithmsAminalonAminaloneAnti-Arrhythmia AgentsAnti-Arrhythmia DrugsAnti-ArrhythmicsAnti-viral AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsAwardBiologicalBloodBlood Reticuloendothelial SystemBrainBrain Nervous SystemCare GiversCaregiversCase SeriesCell Communication and SignalingCell SignalingChildChild YouthChildhoodChildren (0-21)Children's HospitalChronicClinical InvestigatorClinical PharmacologyCollaborationsCommunicable DiseasesConsensusCooperative LearningCoupledDataData BasesDatabasesDiffusionDiseaseDisorderDrug InteractionsDrug ModulationDrug usageDrugsEncephalonEnsureEvaluationEventExperiential LearningExposure toFamilyFeeling suicidalFood and Drug AdministrationGABAGP170GlucocorticoidsGoalsGrippeHigh PrevalenceHistoryHospital AdmissionHospitalizationHospitalsIncidenceInfectionInfectious Disease EpidemiologyInfectious DiseasesInfectious DisorderInfectious EpidemiologyInfluenzaIntracellular Communication and SignalingKidney DiseasesKnowledgeLaboratoriesLeadershipLifeLiteratureMDR-1MDR1MDR1 ProteinMedicaidMedicalMedicationMental disordersMental health disordersMentorsMethodologyMethodsMiscellaneous AntibioticMorbidityMorbidity - disease rateMultidrug Resistance 1Multidrug Resistance Gene-1Multidrug Resistance Gene-1sMultidrug Resistance ProteinsMultidrug Resistant ProteinsN Methyl D aspartic AcidN methyl D aspartateN-Methyl-D-aspartateN-MethylaspartateNMDANephropathyNeurologicNeurologicalObservation researchObservation studyObservational StudyObservational researchOseltamivirOut-patientsOutcomeOutpatientsP-GPP-GlycoproteinP-Glycoprotein 1 GenePGY-1 ProteinPGY1PatientsPediatric HospitalsPediatricsPharmaceutical EpidemiologyPharmaceutical PreparationsPharmaciesPharmacoepidemiologyPharmacologyPharmacy facilityPopulationPopulation StudyProton Pump InhibitorsProviderPsychiatric DiseasePsychiatric DisorderPsychosesRandomization trialRecommendationRecording of previous eventsRenal DiseaseReportingResearchResearch DesignResearch InfrastructureResearch TrainingRetrospective StudiesRetrospective cohort studyRiskSafetySchizophreniaSchizophrenic DisordersSeizuresSignal TransductionSignal Transduction SystemsSignalingSocioeconomically disadvantagedStudy TypeSuicidal thoughtsSuicideSurvey InstrumentSurveysSymptomsSystemTamifluTennesseeTestingTrainingUSFDAUnited States Food and Drug AdministrationViralVital StatisticsWorkanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsarrhythmic agentbiologicbiological signal transductioncareercareer developmentclinical careclinical practicedata basedementia praecoxdesigndesigningdiffuseddiffusesdiffusingdiffusionsdrug epidemiologydrug safetydrug usedrug/agentexperiencefatal attemptfatal suicideflu infectionflu virus infectiongamma-Aminobutyric Acidhigh riskhistoriesimprovedinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfluenza infectioninfluenza virus infectioninhibitorintent to diekidney disorderkidslipophilicitymedication safetymental illnessmortalitymultidisciplinaryneuropsychiatricneuropsychiatric symptomneuropsychiatrypediatricpharmaceutical safetypharmacoepidemiologicpharmacoepidemiologicalpopulation basedpopulation-based studypopulation-level studyprogramspsychiatric co-morbiditypsychiatric comorbiditypsychiatric illnesspsychological disorderrandomized trialrenal disorderschizophrenicsecondary analysisshared decision makingskillssocio-economic disadvantagesocio-economically disadvantagedsocio-economically underprivilegedsocioeconomic disadvantagesocioeconomically underprivilegedstudies of populationsstudy designstudy of the populationsuicidal ideationsuicidal thinkingsuicide ideationsuicidesthoughts about suicideyoungsterΞ³-Aminobutyric Acid
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Description preview
PROJECT SUMMARY/ABSTRACT
Oseltamivir (Tamiflu) is the only Food and Drug Administration (FDA) approved influenza medication for children
< 12 years. Yet, oseltamivir is under prescribed, including in children at high risk for influenza complications. One
key barrier is parental and provider concern about the safety of oseltamivir. Potentialβ¦
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