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Origins of sex differences in the mechanisms of obesity-associated hypertension

Organization AUGUSTA UNIVERSITYLocation AUGUSTA, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldALDOSAdrenal GlandsAdrenalsAdultAdult HumanAffectAldosteroneAldosterone ReceptorAldosterone SynthaseAnabolismAtropineBP controlBP homeostasisBP managementBP regulationBiologyBlood PressureBlood VesselsCYP11B2 geneCardiac ChronotropismCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell SignalingCellsClinical DataCytochrome P450, Subfamily XIB, Polypeptide 2DNA ContentDNA IndexDNA PloidyDataDifferences between sexesDiffers between sexesDissociationEndothelial CellsFemaleFour Core GenotypesFundingGonadal Steroid HormonesGonosomesHealthHeart RateHeart VascularHistoryHuB219HumanHypertensionIn VitroIntracellular Communication and SignalingKnowledgeLEP-RLEPR ProteinLaboratoriesLeptinMeasuresMediatingMenopauseMentorshipMiceMice MammalsMineralocorticoid ReceptorModelingModern ManMolecularMurineMusMyographyOB ReceptorOB-ROb Gene ProductOb ProteinObese Gene ProductObese MiceObese ProteinObesityOophorectomyOutcomeOvariectomyOvaryPhenotypePhysiologyPlayPloidiesPre-MenopausePre-menopausal PeriodPremenopausalPremenopausal PeriodPremenopauseProductionPropanololPropranololReceptor InhibitionReceptor SignalingRecording of previous eventsReportingResearchRisk FactorsRoleSamplingSex ChromosomesSex DifferencesSex HormonesSex Steroid HormonesSexual differencesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSourceSpecificityStAR proteinSteroid 11/18-Beta-HydroxylaseSteroid 18-OxidaseTestingTherapeuticTrainingUniversitiesVascular DiseasesVascular DisorderVascular Hypertensive DiseaseVascular Hypertensive DisorderWomanadipocytokinesadipokinesadiposityadulthoodbiological signal transductionbiosynthesisblood pressure controlblood pressure homeostasisblood pressure managementblood pressure regulationblood vessel disordercardiovascular disease riskcardiovascular disordercardiovascular disorder riskchromosome complementcirculatory systemcorpulencedl-Hyoscyamineexperimentexperimental researchexperimental studyexperimentsfemale gonadectomyfemale sex hormonegonadal steroidshigh blood pressurehistorieshuman femalehyperpiesiahyperpiesishypertensivehypertensive diseasehypertensive disorderimprovedleptin receptorleptin-binding proteinmalemouse modelmurine modelnovelob/ob mouseobesity developmentpost-doctoral trainingpre-docpre-doctoralpre-menopausalpremenopausal statusprotective effectregulate BPregulate blood pressureresponsesexsex based differencessex steroidsex-dependent differencessex-related differencessex-specific differencessocial rolestemsteroidogenic acute regulatory proteinsuprarenal glandtherapeutically effectivevascularvascular dysfunctionvasculopathy♀♂

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PROJECT SUMMARY
Obesity, which affects more than 42% of adults in the US, is the leading risk factor for hypertension. While

premenopausal women are commonly viewed as protected from hypertension and cardiovascular disease,

compelling evidence establishes that obesity abrogates the protective effects of female sex and predisposes

women to vascular…

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Origins of sex differences in the mechanisms of obesity-associated hypertension β€” AUGUSTA UNIVERSITY | UNITED STATES | A | Dev Procure