grant
Orientia tsutsugamsuhi promotes interplay between circadian rhythm and hypoxic responses
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 7 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026ARDSARNTLARNTL geneActive OxygenAcute Respiratory DistressAcute Respiratory Distress SyndromeAdult ARDSAdult RDSAdult Respiratory Distress SyndromeApoptosisApoptosis PathwayAssayBMAL1BacteriaBasal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBlood VesselsBrainBrain Nervous SystemCell BodyCell NucleusCellsChIP SequencingChIP-seqChIPseqCircadian RhythmsClock proteinCo-ImmunoprecipitationsCytoplasmCytosolDNA DamageDNA InjuryDa Nang LungDataDiseaseDisease ProgressionDisorderEmerging infectionEncephalonEndothelial CellsEnsureEnvironmentFatality rateGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic TranscriptionGenomeHeterodimerizationHypoxemiaHypoxiaHypoxia Inducible FactorHypoxicImmuneImmune responseImmunesImmunityInduction of ApoptosisInfectionInnate ImmunityKnowledgeLuciferase ImmunologicLuciferasesMediatingModelingMolecular InteractionMuscleMuscle TissueNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNuclearNucleusNyctohemeral RhythmO tsutsugamushiO. tsutsugamushiOrientia tsutsugamushiOutcomeOutputOxygen DeficiencyOxygen RadicalsPathway interactionsPersonsPhenocopyPost-Transcriptional Gene SilencingPro-OxidantsProcessProductionProgrammed Cell DeathRNA ExpressionRNA InterferenceRNA SilencingRNAiReactive Oxygen SpeciesRegulationRickettsia tsutsugamushiScrub TyphusSequence-Specific Posttranscriptional Gene SilencingShapesShock LungStiff lungTestingTimeTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTsutsugamushi DiseaseTsutsugamushi FeverTwenty-Four Hour RhythmTwo HybridYeast One Hybrid SystemYeast One/Two-Hybrid SystemYeastsanti-microbialantimicrobialaryl hydrocarbon receptor nuclear translocator-likeblue light receptor cryptochromechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcircadiancircadian processcircadian rhythmicitycombatcryptochromedaily biorhythmemergent infectionfitnessgene productgenotoxicityhost responsehypoxemicimmune system responseimmunoresponsemicrobialmolecular clockmuscularmutantpathogenpathwaypharmacologicpreventpreventingpromoterpromotorresponsescreeningscreeningstherapeutic targettranscription factorvascularwet lungyeast 2-hybridyeast two hybrid system
Description preview
SUMMARY
Converting the host cell into a supportive niche is essential for intracellular pathogen survival and replication.
Orientia tsutsugamushi is a genetically intractable obligate intracellular bacterium that causes scrub typhus, a
globally emerging infection with a high fatality rate. Disease progression depends on bacterial-driven modulation…
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