grant

Optimizing the HIV Prevention and Care Continua in the United States

Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 24 Sept 2021Deadline 31 Dec 2027
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS preventionAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAwarenessBehaviorBehavioral SciencesCapitalCaringCessation of lifeCommunitiesCommunity NetworksDataDeathDevelopmentDimensionsDisparitiesDisparityEcological momentary assessmentEpidemicFaceFutureGeographyHIVHIV InfectionsHIV PreventionHIV riskHIV/AIDS preventionHTLV-III InfectionsHTLV-III-LAV InfectionsHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIndividualInfectionInterventionKnowledgeLAV-HTLV-IIILinkLymphadenopathy-Associated VirusMeasuresMethodologyMethodsMobile Health AppMobile Health ApplicationOn-Line SystemsOnline SystemsOutcomeParticipantPathway interactionsPersonsPhasePopulationPopulation StudyPrEPPrevalencePreventiveProcessResearchRespondentRiskRisk BehaviorsRisk ReductionRisky BehaviorSamplingSubgroupTimeTranscendTypologyUnited StatesVirus-HIVVulnerable Populationsat risk behaviorcare outcomescohortdevelopmentalecological momentary interventionexperiencefacesfacialhealth care outcomeshigh riskinnovateinnovationinnovativem-Healthm-Health appm-Health applicationmHealthmHealth appmHealth applicationmobile healthonline computerparticipant enrollmentpathwaypatient enrollmentpopulation-based studypopulation-level studypre-exposure prophylaxisprogramsrecruitreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresilienceresilientresponserisk-reducingsocialsocial epidemiologysocial stigmastigmastudies of populationsstudy of the populationuptakevulnerable groupvulnerable individualvulnerable peopleweb based
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Full Description

Subgroups within the House and Ballroom Community (HBC) account for at least half of all new HIV infections in the United States (U.S.). At the same time there is a significant disparity in knowledge of, access to and uptake of pre-exposure prophylaxis (PrEP) among these subgroups. Individuals in the HBC face stigma and individual, group, societal and structural challenges that put them at high risk of HIV, creating barriers to HIV prevention and care. This study will include a longitudinal qualitative phase, a longitudinal social epidemiologic phase, and an intensive longitudinal ecological momentary assessment phase.

We propose to use an innovative and culturally relevant sampling strategy of web-based respondent driven sampling (webRDS) to recruit an online cohort of 900 people in the HBC. A subgroup of enrolled participants will participate in an ecological momentary assessment (EMA) phase to measure the immediate context of stigma and HIV prevention behaviors and HIV risk. These participants will receive short random ecological momentary assessments daily for 30 days via a mobile health application. Not only will this study examine stigma in context of the daily lives of individuals in the HBC, the EMA phase will also inform future development of a context aware, ecological momentary intervention to reduce HIV risk and optimize the HIV prevention and care continua.

Grant Number: 5DP2AI164315-05
NIH Institute/Center: NIH

Principal Investigator: Sean Arayasirikul

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