grant
Optimizing methadone treatment strategies for opioid use disorder in the era of fentanyl
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 1 Sept 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY202521+ years oldAccelerationActiqAdanonAddressAdultAdult HumanAlthoseAreaBuprenorphineCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCaringCessation of lifeCharacteristicsClinical ProtocolsClinical TreatmentClinical TrialsCommunitiesComplexDataData BasesData LinkagesData SetDatabasesDeathDependenceDolophineDoseDrugsDuragesicED visitER visitEffectivenessElectronic Health RecordEmergency care visitEmergency department visitEmergency hospital visitEmergency medical serviceEmergency room visitEnsureEnvironmentEvaluationFailureFentanestFentanylFentylGoalsGuidelinesHealth Care UtilizationHealth InequityHistoryHomeIndividualInequalities in HealthInequities in HealthInterventionLinkLiteratureMaintenanceMeasuresMedical ExaminersMedicationMedicineMethadoneMethadoseMethodsMinorityMorbidityMorbidity - disease rateOpiatesOpioidOverdosePatient PreferencesPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPersonsPharmaceutical EpidemiologyPharmaceutical PreparationsPharmaciesPharmacoepidemiologyPharmacy facilityPhentanylPhysical DependencePoliciesPopulationPreventionProtocolProtocols documentationQOLQuality of lifeRecord Linkage StudyRecording of previous eventsRecordsRegimenResearchRetrospective cohortRhode IslandRisk ReductionRisk-Benefit AssessmentSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSafetySevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSpecialistStandardizationTherapeuticTimeTitrationsToxicologyTreatment EffectivenessTreatment ProtocolsTreatment RegimenTreatment ScheduleTreatment outcomeUpdateUrineWithdrawalWorkaccess to medicationsaddictionaddictive disorderadministrative data baseadministrative databaseadulthoodassess effectivenessbarrier to carebarrier to health carebarrier to treatmentclinical interventionclinical practiceclinical therapycomparative effectivenesscoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccost effectivenesscravingdata basedeath riskdetermine effectivenessdrug epidemiologydrug/agenteffectiveness assessmenteffectiveness evaluationelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordemergency serviceevaluate effectivenessevidence baseexamine effectivenessexperiencefentanyl useflexibilityflexiblehealth care service usehealth care service utilizationhealth inequalitiesheroin intakeheroin usehistorieshomesimprovedindividual patientmedication accessmedication for opioid use disordermethadone maintenancemethadone maintenance programmethadone maintenance therapymethadone maintenance treatmentmethadone treatmentmortalitymortality risknovelobstacle to careobstacle to health careopiate consumptionopiate drug useopiate intakeopiate overdoseopiate related overdoseopiate toleranceopiate useopiate use disorderopioid consumptionopioid drug overdoseopioid drug useopioid habituationopioid induced overdoseopioid intakeopioid intoxicationopioid medication overdoseopioid overdoseopioid poisoningopioid related overdoseopioid toleranceopioid toxicityopioid treatment programopioid useopioid use disorderoptimal therapiesoptimal treatmentsoverdose deathoverdose fatalitiesoverdose riskpatient oriented outcomespharmacoepidemiologicpharmacoepidemiologicalreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresponseretention rateretention strategyrisk-reducingsevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsocialtolerance to opiatestreatment effecttreatment strategytrial regimentrial treatment
Description preview
PROJECT SUMMARY
Treatment with medications for opioid use disorder is a critical intervention with proven effectiveness for
improving morbidity, mortality and quality of life, yet only a minority of patients with an opioid use disorder are
engaged in treatment and ongoing use of fentanyl during treatment is common. Current methadone treatment…
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