grant
Optical hyperspectral nanoscale chromatin analysis for colon cancer risk-stratification
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY20253-D3-D analysis3-Dimensional3-dimensional analysis3D3D analysisAI AugmentedAI assistedAI basedAI drivenAI enhancedAI integratedAI poweredAdenomatous PolypsAgeAlgorithmsAmericanArtificial Intelligence enhancedAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIBMIBMI percentileBMI z-scoreBiological MarkersBloodBlood Reticuloendothelial SystemBody TissuesBody mass indexCRC screeningCancer CauseCancer EtiologyCancer InductionCancerousCausalityCause of DeathCell BodyCellsCessation of lifeChromatinChromatin StructureClinicalClinical ResearchClinical StudyClinical TrialsColonColon CancerColon CarcinomaColonoscopyColorectal CancerCytologyDNADataDeathDeoxyribonucleic AcidDetectionDevelopmentDiagnosticDistalDropsElectron MicroscopyEligibilityEligibility DeterminationEnrollmentEnsureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyEvaluationFecesFemaleFosteringFutureGenderGene TranscriptionGenetic TranscriptionGenome MappingsGenomicsGoalsGuidelinesHistologicHistologicallyLabelLaboratoriesLengthLesionLinkLocationMeasurableMeasurementMessenger RNAMethodsMicroRNAsMicroscopicMicroscopyMolecularMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular StereochemistryNanoscopyNuclearOpticsPathway interactionsPatientsPerformancePhenotypePlayPolypsPopulationPositionPositioning AttributePrecancerous PolypPredictive ValueProtocol ScreeningQuetelet indexRNA ExpressionRaceRacesRecommendationRectumRegulationResearch ResourcesResourcesRiskRisk FactorsRoleScanningScienceSensitivity and SpecificitySeriesSiteSourceSpecificitySwabTechnologyTestingThree-dimensional analysisTimeTissuesTobaccoTranscriptionTranslatingTransmissionValidationVisitadenomaagesartificial intelligence assistedartificial intelligence augmentedartificial intelligence basedartificial intelligence drivenartificial intelligence integratedartificial intelligence poweredbio-markersbiologic markerbiomarkercancer in the coloncandidate biomarkercandidate markercarcinogenesiscausationclinical practiceclinical translationclinical validationclinically translatablecohortcolon cancer riskcolorectal cancer detectioncolorectal cancer early detectioncolorectal cancer screeningconformationconformationalconformational alterationconformational stateconformationallyconformationscostdemographicsdetect colorectal cancerdevelopmentaldiagnostic technologiesdisease causationelectron tomographyenhanced with AIenhanced with Artificial Intelligenceenrollepigeneticallyinterestliquid biopsymRNAmalemiRNAmolecular dynamicsmucosal layer of the rectumnano meter scalenano meter sizednano-sized sensorsnanocytologynanoimagingnanometer scalenanometer sizednanoscalenanosensingnanosensorsneoplasticnon-compliancenon-compliantnoncompliancenoncompliantopticalpathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespolypoid adenomaprecancerprecancerouspremalignantpreservationpreventpreventingprimary care settingprospectiveracialracial backgroundracial originrectal epitheliumrectal liningrectal mucosarectal mucosal tissuerisk stratificationscreeningscreeningssensing technologysensor technologysensor-based technologysingle moleculesocial rolestoolstratify risktech developmenttechnology developmentthree dimensionaltranscriptomicstransmission processtumoruptakevalidations♀♂
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Description preview
Colorectal cancer (CRC) is the second leading cause of cancer deaths in the U.S. despite being eminently
preventable by colonoscopy. Colonoscopy is the gold standard of CRC screening. Its goal is to identify and
remove premalignant adenomatous polyps with the advanced adenoma being the primary target. According to
guidelines, colonoscopy is…
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