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Opposing Pathways in Mammalian Sex Determination

Organization DUKE UNIVERSITYLocation DURHAM, UNITED STATESPosted 1 Jan 1998Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20253-D modeling3D modelingATAC sequencingATAC-seqATACseqAssay for Transposase-Accessible Chromatin using sequencingBHLH ProteinBasal Transcription FactorBasal transcription factor genesBasic HLH ProteinBasic Helix-Loop-Helix ProteinBasic Helix-Loop-Helix Transcription FactorsBerlinBindingBinding SitesBiological FunctionBiological ProcessCell BodyCell DifferentiationCell Differentiation processCell LineageCellsChIP SequencingChIP-seqChIPseqChromatinChromatin LoopChromatin Loop DomainsCodeCoding SystemCollaborationsCombining SiteCompetenceComplexDNA LoopDNA MethylationData SetDevelopmentDimerizationEmbryoEmbryonicEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitheliumFOXL2FOXL2 geneFamilyFeedbackFemaleForkhead Transcription Factor FOXL2Gene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGonadal structureHTH DNA Binding DomainHTH MotifsHelix-Turn-Helix MotifsHi-CHistonesLicensingLinkLoss of SensationMammaliaMammalsMapsMediatingModelingModificationMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMutant Strains MiceNotch Signaling PathwayNucleosomesNumbnessOvaryPFRKPathway interactionsPituitary Forkhead Factor, Mouse, Homolog ofPolycombPositionPositioning AttributeProtein DimerizationProteinsProteolysis and Signaling Pathway of NotchQuantitative RTPCRQuantitative Reverse Transcriptase PCRRNA ExpressionReactive SiteRepressionSomatic CellStem Cell likeStructureSupporting CellSystemT cell factor 4T cell transcription factor 4T-Cell-Specific Transcription Factor 4TCF-4TCF4TCF7L2TCF7L2 geneTcf4 transcription factorTcf712 transcription factorTesticlesTestingTestisTimeTranscriptionTranscription Factor 7-Like 2Transcription Factor Proto-OncogeneTranscription factor genesWorkassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingcellular differentiationchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingconformationconformationalconformational stateconformationallyconformationsdevelopmentalepigeneticallyglobal gene expressionglobal transcription profilegonadgonadsgranulosa cellhelix loop helixhelix turn helixhistone modificationinhibitormalemethylomemouse mutantmutantnotchnotch proteinnotch receptorspathwayprogenitorprogenitor capacityprogenitor cell likeprogenitor-likepromoterpromotorqRTPCRsertoli cellsex determinationstem cell characteristicsstem-likestemnesstestis sustentacular cellthree-dimensional modelingtranscription factortranscriptome♀♂

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ABSTRACT
Sex determination in mammals is a complex biological process leading to the differentiation of the bipotential
gonad into a testis or ovary. It is initiated by a cell fate decision in a subset of somatic cells called the
supporting cell lineage. These cells carry bivalent histone marks at many genes associated with sex
determination…

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Opposing Pathways in Mammalian Sex Determination — DUKE UNIVERSITY | UNITED STATES | Jan 1998 | Dev Procure