grant
Ontogeny of sex differences in amygdala and hypothalamus after neonatal trauma
Organization UNIVERSITY OF NEW ENGLANDLocation BIDDEFORD, UNITED STATESPosted 1 Aug 2024Deadline 3 Jun 2028
NIHUS FederalResearch GrantFY202521+ years oldACTH-Releasing FactorAbsence of pain sensationAbsence of sensibility to painAdolescentAdolescent YouthAdultAdult HumanAffectAffectiveAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnalgesia TestsAnxietyBehaviorBehavioralBiologicalBiological MarkersBrainBrain Nervous SystemCRF ReceptorsCRF-41CRH ReceptorsCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCommon Rat StrainsComplexCorticoliberinCorticosteroneCorticotropin Releasing-Factor ReceptorsCorticotropin-Releasing FactorCorticotropin-Releasing Factor-41Corticotropin-Releasing HormoneCorticotropin-Releasing Hormone ReceptorsCorticotropin-Releasing Hormone-41Cyclic SomatostatinDataDevelopmentDifferences between sexesDiffers between sexesDiseaseDisorderDown-RegulationDynorphinsDysfunctionEarly TraumaEarly-life traumaEmotionalEncephalonEndocrineExposure toFearFeels no painFemaleFreezingFrightFunctional disorderGene ExpressionGeneralized GrowthGenesGoalsGrowthGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneHistoryHumanHypersensitivityHypothalamic structureHypothalamusImmediate-Early GenesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn Situ HybridizationIndividualInfantInterventionIntracellular Communication and SignalingKnowledgeLifeLiteratureLong-term painMedicalMental DepressionMesencephalic Central GrayMiceMice MammalsMidbrain Central GrayModelingModern ManMoodsMurineMusNatureNeedlesNeonatalNeonatal Intensive Care UnitsNerve CellsNerve UnitNeural CellNeurobiologyNeurocyteNeuroendocrineNeuroendocrine SystemNeurologicNeurologic DysfunctionsNeurologicalNeuronsNeuropeptide GeneNeuropeptidesNeurosecretory SystemsNewborn Intensive Care UnitsNo sensitivity to painNociceptionNociception TestsNucleusOutcomeOutputPainPain AssessmentPain MeasurementPain ThresholdPain Tolerance LevelPain measurePainfulPatientsPatternPeriaqueductal GrayPersistent painPhenotypePhysiologicPhysiologicalPhysiopathologyPituitary-Adrenal SystemPlayPopulationPredispositionProxyPsychologic StressPsychological StressRatRats MammalsRattusRecording of previous eventsRiskRisk FactorsRodentRodentiaRodents MammalsRoleSRIHSRIH-14SensorySeriesSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneSourceStimulusStressSusceptibilitySystemTestingTissue GrowthTraumaWorkadulthoodage associated alterationsage associated changesage associated differenceage based differenceage correlated alterationsage correlated changesage dependent alterationsage dependent changesage dependent differenceage dependent variationage differenceage induced alterationsage induced changesage related alterationsage related changesage related differenceage related variationage specific alterationsage specific changesage specific differenceaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with ageamygdaloid nuclear complexanalgesiaannulus of the aqueductantagonismantagonistantinociceptionantinociceptiveanxiety-like behaviorarmarthritic painarthritis painbehavior responsebehavioral responsebio-markersbiologicbiologic markerbiological adaptation to stressbiological signal transductionbiomarkerbrain circuitrycell typechanges with agechronic painconditioned fearconditioningconstant paincorticotropin releasing hormonedepressiondesigndesigningdevelopmentaldiffer by agedifference across agedifference in ageearly adolescenceearly adversityearly childhood adversityearly life adversityearly life stressexperienceexperimentexperimental researchexperimental studyexperimentsfear conditioninggrowth hormone release inhibiting factorhistorieshypothalamicin situ Hybridization Geneticsin situ Hybridization Staining Methodinnovateinnovationinnovativejuvenilejuvenile humanlasting painlater in lifelater lifelife spanlifespanmalematernal separationmidbrain central gray substancemortalitynegative affectnegative affectivityneonatal ICUneonatal exposureneonatal humanneurobiologicalneurological dysfunctionneuronalneuropathic painnociceptiveon-going painongoing painontogenypain assaypain tolerancepainful neuropathypathophysiologyperiaqueductal gray matterpituitary adrenal axispostnatalpre-clinicalpreclinicalpsychologicpsychologicalpsychological stressespsychological stressorreaction; crisisresponsesexsex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolestress responsestress; reactionstressorvariation by age♀♂
Description preview
Early life medical intervention, such as occurs in the neonatal intensive care unit, saves infant lives, but also is
a significant risk factor for subsequent emotional, mood and sensory dysfunction, including chronic pain.
Critically, there is mounting evidence of significant sex differences in NICU outcomes, with greater mortality
and gross…
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