grant
On circuit mechanisms of reward behaviors after early-life adversity
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202521+ years old4-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidACTH-Releasing FactorAdultAdult HumanAffectAminalonAminaloneAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnhedoniaBehaviorBrainBrain Nervous SystemCRF ReceptorsCRF-41CRH ReceptorsCell BodyCell Communication and SignalingCell SignalingCellsCommon Rat StrainsConsumptionCorticoliberinCorticotropin Releasing-Factor ReceptorsCorticotropin-Releasing FactorCorticotropin-Releasing Factor-41Corticotropin-Releasing HormoneCorticotropin-Releasing Hormone ReceptorsCorticotropin-Releasing Hormone-41DataDepressed moodDrug usageEmotionalEncephalonEquipmentExperimental ModelsExposure toFeelingFemaleFiberFoodGABAGEM modelGEMM modelGeneticGenetically Engineered MouseHealthHistoryHomeHumanIndividualIntracellular Communication and SignalingLifeMajor Depressive DisorderMediatingMental DepressionMental HealthMental HygieneMental disordersMental health disordersMental health promotionMethodsMiceMice MammalsModelingModern ManMolecularMotivationMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeuropeptidesNucleus AccumbensPathway interactionsPhenotypePsychiatric DiseasePsychiatric DisorderPsychological HealthRatRats MammalsRattusReceptor ActivationRecording of previous eventsRewardsRodentRodentiaRodents MammalsRoleSignal TransductionSignal Transduction SystemsSignalingStressTechnologyTestingTransgenic MiceWomanadulthoodamygdaloid nuclear complexantagonismantagonistaxon signalingaxon-glial signalingaxonal signalingbiocytinbiological signal transductionbiotinyl L lysinebrain pathwaycell typeclinical depressioncorticotropin releasing hormonedepresseddepressiondrug useearly adversityearly childhood adversityearly life adversityexperiencefeelingsgamma-Aminobutyric Acidgenetically engineered mouse modelgenetically engineered murine modelglia signalingglial signalinghistorieshomeshuman subjectimmunocytochemistryinsightmajor depressionmajor depression disordermalemenmental illnessnerve signalingneural signalingneuronalneuronal signalingneurotransmissionnovelopen sourceoperationoperationsoptogeneticspathwaypleasurepsychiatric illnesspsychological disordersadnesssexsocial rolesubstance usesubstance usingtemporal measurementtemporal resolutiontime measurementγ-Aminobutyric Acid♀♂
Description preview
SUMMARY
Early-life adversity (ELA) is associated with vulnerability to mental illnesses that involve disruption of
the brain’s reward circuits. These vulnerabilities may manifest as anhedonia, a reduction in reward desire or
pleasure that is core feature of major depression. However, whether the association of ELA with anhedonia is
causal is…
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