grant
Ocular Immune Regulation by Mesenchymal Stem Cells
Organization SCHEPENS EYE RESEARCH INSTITUTELocation BOSTON, UNITED STATESPosted 1 Apr 2015Deadline 14 Sept 2028
NIHUS FederalResearch GrantFY20252B12B1 Bispecific MAb2B1 Bispecific Murine MAbAgonistAllograftingAntigen-Presenting CellsAntigensAutoimmune DiseasesB7-1BB1BindingBispecific Antibody 2B1CD152CD152 AntigenCD152 GeneCD28LGCD28LG1CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD80CD80 geneCTLA 4CTLA-4 GeneCTLA4CTLA4 geneCTLA4-TMCell BodyCell DeathCell FunctionCell MaturationCell PhysiologyCell ProcessCell TherapyCell secretionCell-Mediated Lympholytic CellsCellsCellular FunctionCellular PhysiologyCellular ProcessCellular SecretionCorneaCornea TransplantationCorneal EndotheliumCorneal GraftingCorneal TransplantationCytolytic T-CellCytotoxic T CellCytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Cytotoxic T-Lymphocyte-Associated Protein 4Cytotoxic T-Lymphocyte-Associated Serine Esterase-4Cytotoxic T-LymphocytesDataDevelopmentDiseaseDisorderDown-RegulationFOXP3FOXP3 geneForkhead Box P3FrequenciesGenerationsGoalsGraft RejectionGraft SurvivalGraft ToleranceHomeIFN-GammaIFN-gIFN-γIFNGIFNγImmuneImmune InterferonImmune responseImmunesImmunomodulationImpairmentIn VitroInflammationInflammatoryInterferon GammaInterferon Type IIInvestigationJM2KeratoplastyLAB7LaboratoriesLigandsMediatingMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMiceMice MammalsMoAb 2B1 BispecificMolecularMolecular InteractionMurineMusPathogenicityProliferatingPublishingRegulatory T-LymphocyteReporterReportingResearchResearch PrioritySCURFINSeriesSubcellular ProcessT cell reconstitutionT cell responseT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTherapeuticTransplant RecipientsTransplant RejectionTransplantationTransplantation RejectionTransplantation ToleranceTregWorkaccessory cellalloimmunityautoimmune conditionautoimmune disorderautoimmunity diseasebsAb 2B1cell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapycornealcorneal endothelialcorneal keratoplastycorneal transplantcytotoxiccytotoxic T-lymphocyte antigen 4designdesigningdevelopmentaldraining lymph nodeexperimentexperimental researchexperimental studyexperimentsgraft functionhomeshost responsehuman diseaseimmune modulationimmune regulationimmune system responseimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimprovedinnovateinnovationinnovativeisoimmunitykiller T celllFN-Gammamesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmouse modelmurine modelnecrocytosisnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachocular surfacepreventpreventingreconstitutereconstitutionregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregional lymph noderegulatory T-cellsresponsethymus derived lymphocytetissue regenerationtissue regrowthtissue renewaltissue specific regenerationtransplanttransplant modeltransplant patient
Description preview
SUMMARY: This is a competitive renewal application to further define the immunoregulatory function of mesenchymal stem cells (MSCs) in ocular inflammation. Renowned for promoting tissue regeneration and immune quiescence, studies have demonstrated the therapeutic potential of MSCs in human disease. Nevertheless, fundamental questions remain…
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