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Objective lung assessment tools for improved organ use in lung transplantation

Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 Jul 2021Deadline 31 Aug 2025 ⚠️
NIHUS FederalResearch GrantFY2025AcuteAcute Lung InjuryAcute Pulmonary InjuryAddressAffectAmericanAssessment instrumentAssessment toolBloodBlood Reticuloendothelial SystemBody TemperatureCause of DeathCessation of lifeChronic lung diseaseClinicalCohort StudiesCollaborationsComplexConcurrent StudiesDeathDecision MakingDiseaseDisorderDonor ScreeningDonor SelectionDonor personEarly identificationFearFrightFundingFutureGene ExpressionGrafting ProcedureHourHypoxiaHypoxicImmune Cell ActivationInfiltrationInfrastructureKnowledgeLifeLungLung GraftingLung ParenchymaLung Respiratory SystemLung TissueLung TransplantationLung damageMeasuresMethodsMorbidityMorbidity - disease rateMulti-center studiesMulticenter StudiesNational Institutes of HealthOrganOrgan DonorOrgan ProcurementsOrgan TransplantationOrgan TransplantsOrgan failureOutcomeOxygen DeficiencyP50 MechanismP50 ProgramPathogenesisPathway interactionsPatientsPerfusionPerioperativePopulationPositionPositioning AttributePostoperativePostoperative PeriodPredispositionPreparationPreventiveProbabilityProspective cohortPublic HealthPulmonary GraftPulmonary TransplantPulmonary TransplantationQOLQuality of lifeRadiographyReproducibilityResearchRiskRisk AssessmentRoentgenographySelection CriteriaSignal PathwaySpecialized CenterStructure of parenchyma of lungSusceptibilitySyndromeTLR proteinTechnologyTherapeuticToll-Like Receptor Family GeneToll-Like Receptor PathwayToll-like receptorsTranscriptTransplant RecipientsTransplantationUncertaintyUnited States National Institutes of HealthUpdateWaiting ListsWorkbiomarker identificationcandidate selectionchronic pulmonary diseaseclinical predictorsclinical trial enrollmentcostdoubtgraft dysfunctionhigh riskidentification of biomarkersidentification of new biomarkersimmune activationimplantationimprovedinnate immune pathwayslung injurylung transplantmarker identificationmortalitynew technologynovelnovel technologiesoncology trialorgan allograftorgan graftorgan xenograftpathwaypredictive toolspreparationspreventpreventingprospectivepulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryradiological imagingrisk stratificationstratify risktooltransplanttransplant centerstransplant donortransplant patientventilationwaitlist

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Project Summary/Abstract
Primary graft dysfunction (PGD) is the most common cause of morbidity and mortality after lung
transplantation resulting in significant negative effects on quality of life and cost. PGD has a
complex relationship with donor organ use because uncertainty in organ quality and concern
that poor donor quality causes…

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