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Nutrition-based interventions to ameliorate pain in sickle cell disease
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20255-HT5-Hydroxytryptamine5HT9-ene-TetrahydrocannabinolAbsence of pain sensationAbsence of sensibility to painAddressAffectiveAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAgeAgonistAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAntinociceptive AgentsAntinociceptive DrugsApplications GrantsAreaBehavioralBirthBlood DiseasesBody TissuesBrainBrain Nervous SystemBrain regionBreedingCB1CB1 ReceptorCB1RCNR1 geneCannabidiolCannabinoid Receptor CB1CannabinoidsCell Communication and SignalingCell SignalingChronicChronic DiseaseChronic IllnessClinicalClinical ResearchClinical StudyCognitiveCognitive DiscriminationCollaborationsD9-tetrahydrocannabinolDA NeuronDataDelta-9-TetrahydrocannabinolDetectionDevelopmentDietDietary InterventionDiscriminationDopamineDopamine neuronDorsal Horn CellsDorsal Horn NeuronsDorsal Horn of the Spinal CordDoseEncephalonEndocannabinoidsEndogenous CannabinoidsEnteramineEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvaluationEyeEyeballFatsFatty acid glycerol estersFeels no painFemaleGene ExpressionGestationGoalsGrant ProposalsHSC transplantationHb SS diseaseHbASHbSS diseaseHead circumferenceHealthHealth BenefitHematologic DiseasesHematological DiseaseHematological DisorderHematopoietic Stem Cell TransplantHematopoietic Stem Cell TransplantationHemoglobin S DiseaseHemoglobin sickle cell diseaseHemoglobin sickle cell disorderHereditaryHippophaineHydroxycarbamidHydroxycarbamideHydroxytyramineHyperalgesiaHyperalgesic SensationsHypersensitivityIndividualInheritedInterventionIntracellular Communication and SignalingLatin AmericanLearningLengthLifeLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMalnutritionMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMentorsMesencephalic Central GrayMiceMice MammalsMidbrain Central GrayMurineMusN arachidonoyl 2 hydroxyethylamideN-3 polyunsaturated fatty acidN-arachidonoylethanolamineNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeurocyteNeuronsNeurotransmittersNo sensitivity to painNociceptionNutrientNutritionNutrition InterventionsNutritionalNutritional DeficiencyNutritional InterventionsObesityOmega-3 Fatty AcidsOmega-3 PUFAOmega-3 Polyunsaturated Fatty AcidOmega3OpiatesOpioidOutcomePETPET ScanPET imagingPETSCANPETTPainPainfulParentsParturitionPathologicPathway interactionsPerceptionPeriaqueductal GrayPerinatalPeripartumPersonsPhasePlayPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPosterior Horn CellsPosterior Horn NeuronsPregnancyPreventionPropertyRad.-PETResearch ResourcesResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingResourcesRewardsRiskRoleSensorySerotoninSickle Cell AnemiaSickle Cell TraitSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSocial isolationSpinal cord posterior hornSynapsesSynapticTechniquesTeratogenicTeratogenic effectsTeratogenicityTeratogensTetrahydrocannabinolTissuesTrainingTransgenic OrganismsUndernutritionUnited StatesVentral Tegmental AreaVulnerable PopulationsWeaningadiposityadverse consequenceadverse outcomeagesanalgesiaanaloganandamideannulus of the aqueductarachidonoyl ethanolamidearachidonoylethanolamidearachidonylethanolamidebehavior measurementbehavioral measurebehavioral measurementbiological signal transductionblood disorderblood stem cell transplantationcannabinoid receptorcannabinoid receptor 1cannabinoid receptor type 1cannabinoid type 1cell typechronic disorderchronic painchronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentco-morbidco-morbiditycognitive functioncomorbiditycorpulencedelta(1)-THCdelta(1)-Tetrahydrocannabinoldelta(9)-THCdelta(9)-Tetrahydrocannabinoldevelopmentaldiet interventiondietarydietary deficiencydietary manipulationdietsdopaminergic neurondorsal horneCB systemeffective therapyeffective treatmentendocannabinoid systemendogenous cannabinoid systemenvironmental riskepigeneticallyepigenomeepigenomicsexperiencehematopoietic cell transplantationhematopoietic cellular transplantationhematopoietic progenitor cell transplantationhydroxy-ureahydroxyureahyperalgiaimmunoreactivityimprovedinfancyinfantileinhibit paininsightmalemalnourishedmidbrain central gray substancen-3 Fatty Acidsn-3 PUFAneural imagingneuro-imagingneuroimagingneurological imagingneuronalnociceptivenovelnutrition deficiencynutrition deficiency disordernutritional deficiency disordernutritiousoffspringomega-3omega-3sopiate consumptionopiate drug useopiate intakeopiate therapyopiate useopioid consumptionopioid drug useopioid intakeopioid therapyopioid usepain inhibitionpain killerpain medicationpain outcomepain reductionpain relieverpain signalpain-related outcomepainkillerparentpathwayperiaqueductal gray matterpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostnatalpreventpreventingprospectivereduce painresponse to therapyresponse to treatmentsickle cell diseasesickle cell disordersickle diseasesicklemiasicklingskillssocial rolesocial stigmasomatosensoryspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstandard of carestigmasynapsetherapeutic responsetherapy responsetransgenictranslational opportunitiestranslational potentialtreat chronic paintreatment responsetreatment responsivenessventral tegmentumvulnerable groupvulnerable individualvulnerable peopleΔ(1)-THCΔ(1)-tetrahydrocannabinolΔ(9)-THCΔ(9)-tetrahydrocannabinolΔ-9-tetrahydrocannabinolΔ9-tetrahydrocannabinol♀♂
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Description preview
PROJECT SUMMARY/ABSTRACT
Integrative approaches, including nutrition, to address pain suffer from a paucity of mechanistic understanding,
which often disproportionately impacts vulnerable populations. Affective modulation of pain in chronic disease
remains an unmet need, however personalized, accessible approaches utilizing diet may provide…
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