grant
NRG Oncology NCORP Research Base-BIQSFP
Organization NRG ONCOLOGY FOUNDATION, INC.Location PHILADELPHIA, UNITED STATESPosted 11 Jul 2025Deadline 31 Jul 2026
NIHUS FederalResearch GrantFY20252-APPD21+ years old65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldABPPAccess to CareAccountingActive Follow-upAddressAdjuvantAdjuvant TherapyAdministratorAdoptedAdultAdult HumanAdvisory CommitteesAdvocateAffectAfter CareAfter-TreatmentAftercareAgarAged 65 and OverAmericanAmmon HornAnti-VEGFAnti-VEGF Humanized Monoclonal AntibodyAnti-VEGF RhuMAbAreaAuthorizationAuthorization documentationBackBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavior assessmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBlindedBlindnessBoard CertificationBone MarrowBone Marrow Reticuloendothelial SystemBrainBrain DiseasesBrain DisordersBrain MetastasisBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsBreast CancerBreast MetastasisBudgetsBusinessesCAT scanCCOPCNS TumorCNS neoplasmCT X RayCT XrayCT imagingCT scanCalendarCancer CenterCancer ControlCancer Control ResearchCancer Control ScienceCancer PatientCancer TreatmentCancersCaringCase Report FormCell CompartmentationCell CompartmentationsCentral Nervous System NeoplasmsCentral Nervous System TumorsCertificationCessation of lifeCharacteristicsChemotherapy and RadiationChemotherapy and/or radiationChronicClinicClinicalClinical Cooperative GroupsClinical OncologyClinical Research AssociateClinical Trial GroupsClinical TrialsClinical Trials Cooperative GroupClinical Trials DesignCodeCoding SystemCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsCollectionCommunitiesCommunity Clinical Oncology ProgramCommunity OncologyCommunity PhysicianCompetenceComplementComplement ProteinsComputed TomographyComputer softwareComputersConcept ReviewConditioning TherapyConfidence IntervalsConsentConsultContracting OpportunitiesContractsCopyrightCornu AmmonisCorrelative StudyCost SharingCranial IrradiationCredentialingDNA-6-O-Methylguanine[protein]-L-Cysteine S-MethyltransferaseDataData AdjustmentsData AnalysesData AnalysisData BasesData CollectionData Management CoreData SystemsDatabasesDeathDedicationsDeteriorationDevelopmentDiminished VisionDiseaseDisorderDisparitiesDisparityDisturbance in cognitionDoctor of PhilosophyDorsumDoseE-MailEC 2.1.1.63EGF ReceptorEGFRERBB ProteinEducationEducation and TrainingEducational aspectsEducational workshopElderlyElectronic MailElectronicsEligibilityEligibility DeterminationEmailEncephalonEncephalon DiseasesEnrollmentEnsureEnvironmentEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsEpilepsyEpileptic SeizuresEpilepticsEpisodic memoryEthnic OriginEthnicityEvaluableEvaluable DiseaseEvaluationEventEvidence based interventionExclusionExposure toFacilities and Administrative CostsFailureFamilyFamily memberFaxFeesFemale HealthFoundationsFriendsFundingGOGGadoliniumGd elementGenderGeneticGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrantGuanine-O(6)-AlkyltransferaseGuidelinesGynecologic Oncology GroupHER1Health Care ProvidersHealth Care TeamHealth Disparities ResearchHealth PersonnelHealth Services AccessibilityHealth disparities related researchHippocampusHospice CareHumanHuman ResourcesIQ DeficitIT SystemsIatrogenic CancerImageImmune mediated therapyImmunologically Directed TherapyImmunotherapyImpaired cognitionIncidenceIndirect CostsIndividualInformation SystemsInformation TechnologyInformation Technology SystemsInfrastructureInstitutionInstructionInternationalInterventionIntervention TrialInterventional trialIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigatorsLeadershipLettersLightLocal CancerLocal TherapyLocalized CancerLocalized MalignancyLocalized Malignant NeoplasmLocalized TherapyLow VisionLymphedemaMDACCMGMTMGMT geneMalignant Breast NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorManpowerManualsMeasurementMeasuresMedical Care TeamMemantinMemantineMemoryMentorshipMetastatic Neoplasm to the BrainMetastatic Tumor to the BrainMetastatic malignant neoplasm to brainMethodologyMethodsMethylated-DNA Protein-Cysteine MethyltransferaseMethylated-DNA-Protein-Cysteine S-MethyltransferaseMethylguanine-DNA Methyltransferase GeneMiceMice MammalsMinorityMoAb VEGFModalityModelingModern ManModificationMolecularMonitorMonoclonal Antibody Anti-VEGFMurineMusMutismMyeloid ProgenitorMyeloid Progenitor CellsMyeloid Stem CellsNCCTGNCI OrganizationNSABPNSCLCNSCLC - Non-Small Cell Lung CancerNational Cancer InstituteNational Clinical Trials NetworkNational Institutes of HealthNational Surgical Adjuvant Breast and Bowel ProjectNatureNervous System PhysiologyNeural Stem CellNeurocognitionNeurocognitiveNeurocognitive DeficitNeuroglial NeoplasmNeuroglial TumorNeurologicNeurologic functionNeurologicalNeurological disabilityNeurological functionNeuropsychologic TestsNeuropsychological TestsNeuropsychologiesNeuropsychologyNewly DiagnosedNon-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaNon-adherent patientNonadherent patientNormal TissueNormal tissue morphologyNorth Central Cancer Treatment GroupNotificationNursesO(6)-AGTO(6)-Alkylguanine-DNA AlkyltransferaseO(6)-MeG-DNA MethyltransferaseO(6)-Methylguanine DNA TransmethylaseO(6)-Methylguanine MethyltransferaseO(6)-Methylguanine-DNA MethyltransferaseO6-Alkylguanine DNA AlkyltransferaseOat cell carcinomaOn-Line SystemsOncologyOncology CancerOnline SystemsOperative ProceduresOperative Surgical ProceduresOralOutcomeOutcome StudyOutcomes ResearchPalliative CarePalliative TherapyPalliative TreatmentPartial SightParticipantPatient CompliancePatient MonitoringPatient Non CompliancePatient Non-AdherencePatient NonadherencePatient NoncompliancePatient Outcomes AssessmentsPatient ParticipationPatient Reported MeasuresPatient Reported OutcomesPatient SelectionPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPerformancePermissionPh.D.PhDPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhasePhonePhotoradiationPhysiciansPhysiologic pulsePopulationPostoperativePostoperative PeriodPre-Clinical ModelPreclinical ModelsPreventionPricePrimary Brain NeoplasmsPrimary Brain TumorsPrimary CarePrincipal InvestigatorPrintingProbabilityProceduresProgressive DiseasePropertyProphylactic Cranial IrradiationProtocolProtocol ScreeningProtocols documentationPsychologistPsychometricsPsychotherapyPublishingPulseQOLQOL improvementQuality ControlQuality of lifeRTOGRaceRacesRadiationRadiation OncologyRadiation SurgeryRadiation Therapy Oncology GroupRadiation therapyRadiosurgeryRadiotherapeuticsRadiotherapyRandomization trialRandomizedRandomized, Controlled TrialsReadingRecombinant Humanized Anti-VEGF Monoclonal AntibodyRecombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth FactorRecommendationRecurrenceRecurrentReduced VisionReportingResearchResearch PersonnelResearch ResourcesResearchersResectedResolutionResourcesRhuMAb VEGFRiskRisk ReductionRural PopulationRural groupRural peopleSWOGSample SizeSamplingScheduleSecondary toSecureSecuritySeizure DisorderSensorySeriesSeveritiesSex FunctioningSideSiteSmall Cell Lung CancerSocietiesSoftwareSolid NeoplasmSolid TumorSouthwest Oncology GroupSpecific qualifier valueSpecifiedSpeedStagingStandardizationStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStep retrainingStep trainingStereotactic External Beam IrradiationStereotactic RadiosurgeryStereotaxic RadiosurgerySterotactic External Beam RadiationStratificationStudy SubjectSubnormal VisionSurgicalSurgical InterventionsSurgical ProcedureSurvey InstrumentSurveysSurvivorsSymptomsTGF-alpha ReceptorTask ForcesTechniquesTeleconferencesTelefacsimileTelefaxTelephoneTemodalTemodarTemporal LobeTest ResultTestingTherapeutic Clinical TrialTherapeutic TrialsTherapy Related Malignant NeoplasmTherapy Related Malignant TumorTherapy-Associated CancersTherapy-Related CancerTimeTomodensitometryToxic effectToxicitiesTrail Making TestTrainingTraining ActivityTraining ProgramsTraining and EducationTransforming Growth Factor alpha ReceptorTranslational ResearchTranslational ScienceTreatment-Associated CancerTreatment-Related CancerUnited StatesUnited States National Institutes of HealthUniversity of Texas M D Anderson Cancer CenterUniversity of Texas MD Anderson Cancer CenterUpdateUrbanicityUrogastrone ReceptorVascularizationVendorVerbal LearningVisitVisual impairmentWithdrawalWomanWomen's HealthWord Association TestsWorkWorkshopX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXenograft ModelXray CAT scanXray Computed TomographyXray computerized tomographyabove age 65access to health servicesaccess to servicesaccess to treatmentaccessibility to health servicesactive followupadjuvant treatmentadulthoodadvanced ageadvisory teamafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardage stratificationaged 65 and greateraged 65+aged ≥65alkylguanine DNA alkyltransferaseanti-cancer researchanti-cancer therapyarmavailability of servicesbasebasesbehavior interventionbehavioral assessmentbehavioral interventionbevacizumabbiomarker evaluationbrain irradiationbrain micrometastasisbrain radiationbreast cancer metastasisbropiriminec-erbB-1c-erbB-1 Proteincancer carecancer diagnosiscancer disparitycancer health disparitycancer microenvironmentcancer preventioncancer researchcancer riskcancer therapycancer-directed therapycancer-related health disparitycare accesscare deliverycare outcomescatscanchemo/radiation therapychemotherapy and radiotherapyclinical careclinical imagingclinical outcome assessmentclinical practiceclinical significanceclinically significantcluster randomized designcognitive dysfunctioncognitive functioncognitive losscohortcomfort carecompare costcomplementationcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographyconsultscostcost comparisoncost effectivenesscranial radiationdata basedata cleaningdata cleansingdata imputationdata integritydata interpretationdata managementdata management and coordinating centerdata management centerdata to traindataset to traindeath riskdesigndesigningdevelopmentaldigitaldisease riskdisorder riskdisparity in cancerdisparity in healthdistractiondouble-blind placebo control trialdouble-blind placebo controlled trialdouble-masked controlled trialdrug developmenteffectiveness testingelderly patientelectronicelectronic communicationelectronic deviceenrollepilepsiaepileptogenicerbB-1erbB-1 Proto-Oncogene ProteinerbBlethnic minorityevidence baseexecutive controlexecutive functionexperienceexperimentexperimental researchexperimental studyexperimentsfollow upfollow-upfollowed upfollowupfunctional independencegeriatricglial-derived tumorglioblastoma multiformehazardhealth care outcomeshealth care personnelhealth care workerhealth disparities sciencehealth disparityhealth providerhealth related quality of lifehealth service accesshealth services availabilityhealth traininghealth workforcehippocampalhuman modelhuman old age (65+)imagingimaging studyimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedimprovements in QOLimprovements in quality of lifeimputation methodindexinginjury to the vasculatureinjury to tissueinnovateinnovationinnovativeinstrumentintelligence quotient deficitinterestintervention armintervention designirradiationlab equipmentlaboratory equipmentlaboratory technologylung oat cell carcinomalung small cell neuroendocrine carcinomalymph edemalymphatic edemamalignancymalignant breast tumormanage symptommarker evaluationmedical personnelmeetingmeetingsmembermethazolastonemethylguanine DNA methyltransferasemicroPET/CTmodel of humanmortality riskmultidisciplinarymyeloid precursormyeloid stem and progenitor cellneoplasm/cancernerve cell deathnerve cell lossnerve stem cellnervous system functionneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneuro-oncologyneurocognitive declineneurocognitive impairmentneurocognitive testneurogenic progenitorsneurogenic stem cellneuroglia neoplasmneuroglia tumorneuron cell deathneuron cell lossneuron deathneuron lossneuron progenitorsneuron toxicityneuronal cell deathneuronal cell lossneuronal deathneuronal lossneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuronal toxicityneurooncologyneuroprogenitorneuropsychologicneurotoxicneurotoxicitynext generationnon-compliancenon-compliantnon-contrast CTnoncompliancenoncompliantnoncontrast CTnoncontrast computed tomographynurseoat cell cancerolder patientoncology programonline computerover 65 yearspalliative interventionpatient adherencepatient centeredpatient cooperationpatient orientedpatient oriented outcomespatient populationperformance sitepersonnelpharmaceuticalphase 2 studyphase 2 trialphase 3 trialphase II studyphase II trialphase III trialpost treatmentpre-clinicalpreclinicalpreservationpricingprimary end pointprimary endpointprocessing speedprofessorprogenitor and neural stem cellsprogramspromoterpromotorprospectiveproto-oncogene protein c-erbB-1psychologicpsychologicalquality assurancequality of life improvementracialracial backgroundracial minorityracial originradiation deliveryradiation effectradiation or chemotherapyradiation treatmentrandomisationrandomizationrandomized control trialrandomized trialrandomized, clinical trialsrandomly assignedreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresolutionsresponserhuMabVEGFrisk-reducingrural individualscreeningscreeningssenior citizenservice availabilitysexual functioningsmall cell lung carcinomasmall cell undifferentiated carcinomaspongioblastoma multiformestandard of carestatistical analysisstatisticssurgerysurvival outcomesurvivorshipsymptom managementsymptom sciencetemozolomidetemporal cortextherapeutic evaluationtherapeutic testingtherapy designtimelinetissue injurytooltraining datatraining moduletranslation researchtranslational investigationtreatment accesstreatment armtreatment designtreatment effecttreatment providertreatment trialtreatment with radiationtrial comparingtrial designtumortumor diagnosistumor microenvironmenttumor of the central nervous systemtumors in the braintumors in the central nervous systemunder served communityunderserved communityvascular injuryverbalvision impairmentvision lossvisual lossvisually impairedvolunteerweb basedweb-accessiblework groupworking groupxenograft transplant modelxenotransplant model≥65 years
Full Description
The objective of this proposal is to establish and maintain the NCORP (National Community
Oncology Research Program) for the NRG Oncology research base. The NRG NCORP is the
result of aligning the legacy CCOPs (Community Clinical Oncology Programs) from three NCI
Cancer Cooperative Groups: NSABP, RTOG and GOG. These groups together have over
almost 100 years of combined experience serving as CCOP Research Bases. NRG NCORP,
comprised of a multi-disciplinary team of investigators and patient advocates, is poised to carry
out the objectives of: 1) designing and conducting cancer prevention, control and screening
clinical trials; 2) designing and embedding patient reported outcomes in both primary NCOPR
trials as well as NRG therapeutic trials 3) designing and conducting cancer care delivery
research; 4) enhancing community access to treatment and imaging trials conducted under the
National Clinical Trials Network (NCTN) and 5) conducting primary intervention trials and
integrating health disparity research questions into cancer care delivery research and treatment
trials. To allow NRG NCORP to meet these goals, the group will: participate fully in NRG
Oncology leadership and will determine the scientific direction and prioritization of the NRG
NCORP activities and resources and oversee the translational research, clinical trial activities,
and correlative studies related to the aims of NRG NCORP. With the NRG Statistical and Data
Management Center (SDMC), this team will provide efficient, methodologically up-to-date trial
design with a focus on NCORP specific needs such as patient-reported repeated longitudinal
assessments and cluster-randomized designs. NRG NCORP will provide study monitoring,
reporting, and analysis; build an infrastructure to support our cancer care delivery research
agenda; provide comprehensive data management quality control and quality assurance
programs to ensure high data integrity and timely data for analysis; leverage cutting edge
information technology emphasizing security, timeliness, and efficiency of data collection and
management; providing RT credentialing and quality assurance; and provide education and
training for institutional Clinical Research Associates, Study Chairs, local Principal Investigators
and others involved in the NRG NCORP research agenda. Further, to accomplish these aims
NRG NCORP will engage fully with NCI-designated NCORP community physicians and patient
advocates as well as the NCI and other NCI-sponsored entities (cooperative groups, cancer
centers, SPOREs) to collaborate across the NCTN to improve cancer prevention and control,
cancer care and outcomes, and quality of life for patients affected by cancer.
Grant Number: 3UG1CA189867-11S2
NIH Institute/Center: NIH
Principal Investigator: Deborah Bruner
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