grant
NRF2 suppression of inflammatory signaling and its role in tumor progression
Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 5 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AffectAntioxidantsAutopsyAutoregulationBasal Transcription FactorBasal transcription factor genesBreast CancerBreast Cancer CellBreast Cancer ModelBreast Cancer PatientBreast MetastasisBreast NeoplasmsBreast Tumor PatientBreast TumorsBreast tumor modelCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancersCarcinomaCause of DeathCell BodyCell Communication and SignalingCell SignalingCellsCessation of lifeCytotoxic ChemotherapyCytotoxic TherapyDataDeathDiseaseDisorderDistantEpistasisEpistatic DeviationEpithelial cancerGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenetic EpistasisGenetic TranscriptionGoalsGrowthHomeostasisHumanImmuneImmune infiltratesImmunesInfiltrationInflammatoryInteraction DeviationIntermediary MetabolismIntracellular Communication and SignalingIsogeneic HomograftIsogeneic TransplantationIsogenic transplantationIsograftKnock-outKnockoutMalignant Breast NeoplasmMalignant CellMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant NeoplasmsMalignant TumorMammary CancerMammary NeoplasmsMediatingMetabolicMetabolic PathwayMetabolic ProcessesMetabolic stressMetabolismMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMetastatic breast cancerMetastatic/RecurrentMiceMice MammalsModern ManMurineMusNeoplasm MetastasisNucleotide SynthesisNutrient availabilityOxidation-ReductionOxidative StressPathway interactionsPatientsPhysiological HomeostasisProcessPublishingPurines/Pyrimidines/Nucleotides/Nucleic Acids MetabolismPyrimidineRNA ExpressionRecurrenceRecurrentRecurrent Malignant NeoplasmRecurrent Malignant TumorRecurrent NeoplasmRecurrent tumorRedoxRegulationRelapseResearchResistanceRiskRoleSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSiteSyngeneic HomograftSyngeneic TransplantationTestingTherapeuticTissue GrowthTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTumor CellTumor PromotionWomanWomen's mortalityWorkanalyze gene expressionbiological adaptation to stressbiological signal transductionbreast cancer metastasisbreast cancer progressionbreast tumor cellcancer cellcancer metastasiscancer microenvironmentcancer progressioncancer recurrencechemotherapyclustered regularly interspaced short palindromic repeats screencohortdeath among femalesdeath among womendeath in femalesdeath in womendeath rate among womendeath rate in womendevelop therapyepistatic interactionepistatic relationshipepithelial carcinomaexperimentexperimental researchexperimental studyexperimentsfemale deathfemale mortalitygene expression analysisgene expression assaygene x gene interactiongenetic epistasesimmune cell infiltrateimmune microenvironmentimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedin vivoindividuals with breast cancerintervention developmentknock-downknockdownmalignancymalignant breast tumormammary cancer modelmammary tumormammary tumor modelmetastatic breast tumormetastatic mammary cancermetastatic mammary tumormolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentmortality among femalesmortality among womenmortality in femalesmortality in womenmouse modelmurine modelnecropsyneoplasm progressionneoplasm recurrenceneoplasm/cancerneoplastic cellneoplastic progressionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynucleotide metabolismontogenyoxidation reduction reactionpathwaypatients with breast cancerperson with breast cancerpostmortempreventpreventingprogramsreaction; crisisresistance to therapyresistantresistant to therapysocial rolestress responsestress; reactiontargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic resistancetherapy developmenttherapy resistanttranscription factortranscriptional profilingtransplant modeltreatment developmenttreatment resistancetumortumor cell metastasistumor growthtumor immune microenvironmenttumor microenvironmenttumor progressiontumor-immune system interactionswomen's deathwomen's death rate
Description preview
Project Summary/Abstract
Tumor metastasis is responsible for the vast majority of deaths from epithelial cancers, including breast
cancer. Understanding how cancer cells spread to distant sites, persist as dormant disseminated tumor cells
(DTCs), and eventually recur is essential to improving the treatment of this disease. The long-term goal of…
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