grant

Novel Tumor Suppressing Kinases in Cancer

Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AllelesAllelomorphsApesAssayB-raf-1BRAFBRAF geneBioassayBiochemicalBioinformaticsBiological AssayCancersCommunitiesCultured CellsDNA AlterationDNA Sequence AlterationDNA mutationDependenceDevelopmentEvaluationGene AlterationGene MutationGeneticGenetic AlterationGenetic ChangeGenetic defectGenetic mutationGenomic approachGoalsHumanKinasesKnowledgeMalignant NeoplasmsMalignant TumorModern ManMolecularMonitorMutationOncogenesisOncogenicPathway interactionsPatientsPhenotypePhosphotransferase GenePhosphotransferasesProcessRAFB1ResearchSequence AlterationShort interfering RNASmall Interfering RNASomatic MutationTransphosphorylasescancer genomicsdevelopmentaldriver lesiondriver mutationdrug developmentfunctional genomicsfunctional restorationgene defectgenome editinggenome mutationgenomic alterationgenomic editinggenomic effortgenomic strategyin vivoloss of functionloss of function mutationmalignancymutantmutant alleleneoplasm/cancernoveloncogenomicspathwayresponserestore functionrestore functionalityrestore lost functionsiRNAsomatic variantspatial and temporalspatial temporalspatiotemporaltargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttumortumorigenesisv-raf Murine Sarcoma Viral Oncogene Homolog B1
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Description preview

Cancer genomic sequencing has significantly impacted our understanding of the temporal and spatial genetic alterations that lead to tumorigenesis. This information enables the development of targeted therapies that result in durable and less toxic responses in patients. In regard to kinases, the biomedical community has focused research efforts on…

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Novel Tumor Suppressing Kinases in Cancer — DIVISION OF BASIC SCIENCES - NCI | UNITED STATES | Dev Procure