grant
Novel tools for measuring typhoid vaccine impact
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years old7S Gamma GlobulinAbdominal TyphusAddressAdoptionAdultAdult HumanAntigensAntimicrobial ResistanceAssayBacteriophagesBioassayBiological AssayBloodBlood Reticuloendothelial SystemCessation of lifeChildChild YouthChildren (0-21)ClinicalCluster randomization trialCluster randomized trialCollectionCommunitiesConjugate VaccinesCountryDataDeathDetectionDevelopmentDiagnosisDiagnosticDiseaseDisorderDrynessEconomic IncomeEconomical IncomeEffectivenessEnrollmentEnteric FeverGeneticGenomicsGoalsHaplotypesHealth systemHumanHydrogen OxideIgGImmunoglobulin GIncidenceIncomeIndiaIndividualInfectionInfrastructureInternationalIntestinalIntestinesKnowledgeLMICLaboratoriesLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMeasuresMethodsModelingModern ManMonitorMorbidityMorbidity - disease rateParticipantPatternPhagesPhasePopulationPopulation SizesPublic HealthRandomization trialRandomizedRecommendationReference StandardsResearch ResourcesResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingResourcesRiskS entericaS enterica serovar TyphiS typhiS typhosaS. entericaS. enterica serovar TyphiS. typhiS. typhosaSalmonella entericaSalmonella enterica serovar TyphiSalmonella typhiSalmonella typhosaSanitationSerologySerotypingSourceSpottingsSurveillance MethodsTestingTimeTranslatingTransmissionTyphoidTyphoid FeverTyphoid VaccineVaccinatedVaccinationVaccinesWateradulthoodanti-microbial resistantarmbacterial virusbowelburden of diseaseburden of illnessburden to communitycommunity burdencostdensitydevelopmentaldiagnosis standarddisease burdenenrollentire genomeepidemiological modelevaluate vaccinesfull genomegenome sequencingimmunogenimprovedincomesinnovateinnovationinnovativekidslow and middle-income countriesnew approachesnovelnovel approachesnovel strategiesnovel strategypopulation basedpreventpreventingprogramsprospectiverandomisationrandomizationrandomized trialrandomly assignedresistance strainresistance to anti-microbialresistant strainresistant to antimicrobialresponseserological markerserology surveyserosurveytooltransmission processvaccination studyvaccination trialvaccine evaluationvaccine screeningvaccine studyvaccine testingvaccine trialwaste water based surveillancewaste water surveillancewastewater based surveillancewastewater surveillancewhole genomeyoungster
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Project Summary
Typhoid fever is a leading cause of invasive bacterial illness and death worldwide, with
the majority of infections occurring in low- and middle-income countries where water and
sanitation infrastructure is poor. Highly antimicrobial-resistant strains of Salmonella
Typhi have been emerging and spreading internationally and…
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