grant
Novel Roles for IRE1 in Regulating Cardiac Fibrosis
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253-D Imaging3D imagingAccountingAcuteAffectAnatomic SitesAnatomic structuresAnatomyBasal Transcription FactorBasal transcription factor genesBiochemicalBiopsy SampleBiopsy SpecimenBody TissuesCardiacCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiocyteCardiovascular DiseasesCausalityCause of DeathCell Communication and SignalingCell SignalingCell-Extracellular MatrixCessation of lifeChemicalsChiro-InositolChronicClinicalCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCoupledDataDeathDepositDepositionDevelopmentDisease ProgressionECMEFRACER stressEconomic BurdenEjection FractionEndoplasmic ReticulumEnzyme GeneEnzymesErgastoplasmEtiologyExtracellular MatrixExtracellular Matrix ProteinsFibroblastsFibrosisFibrosis in the heartFibrosis in the myocardiumFibrosis within the heartFibrosis within the myocardiumFibrotic myocardiumGene TargetingGeneral Transcription Factor GeneGeneral Transcription FactorsGoalsHeartHeart DiseasesHeart Muscle CellsHeart failureHeart myocyteHourHumanImpairmentIn VitroIncidenceIndividualInositolInterventionIntracellular Communication and SignalingInvestigationLV remodelingLeftLeft Ventricular RemodelingLiver FibrosisMeasuresMediatingMedicalMesoinositolMessenger RNAMetabolicMetabolic syndromeMiceMice MammalsModelingModern ManMolecularMolecular ProbesMorphologyMurineMusMyofibroblastPathogenesisPathologicPerivascular FibrosisPlayPre-Clinical ModelPreclinical ModelsProcollagenProteinsQuality ControlRNA NucleasesRNaseRegulationRibonuclease Family ProteinRibonucleasesRoleSignal TransductionSignal Transduction SystemsSignalingStimulusTactileTestingTherapeuticThree-Dimensional ImagingTissuesTranscription Factor Proto-OncogeneTranscription factor genesTreatment EfficacyUnited StatesVentricularXBP1XBP1 geneadverse consequenceadverse outcomearmatherosclerotic coronary diseasebiological signal transductioncardiac MRIcardiac failurecardiac fibrosiscardiac magnetic resonance imagingcardiomyocytecardiovascular disordercausationcell typecomparativecoronary arterial diseasecoronary fibrosisdecline in functiondecline in functional statusdevelopmentaldisease causationendonucleaseendoplasmic reticulum stressfibrotic heartfibrotic liverfunctional declinefunctional status declinegene signaturesgenetic signatureglobal gene expressionglobal transcription profileheart disorderheart failure and reduced ejection fractionheart failure with reduced ejection fractionheart fibrosishepatic fibrosisin vivointerstitialintervention efficacyleft ventricle remodelingmRNAmRNA DegradationmRNA Transcript Degradationmortalitymouse modelmurine modelmyocardial fibrosisnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoverexpressoverexpressionpharmacologicpreservationpressureprotective effectprotein foldingprotein homeostasisproteostasisresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall moleculesocial roletherapeutic efficacytherapy efficacytranscription factortranscriptometranscriptomicsvirtual
Description preview
Project Summary:
Cardiovascular disease has consistently been the leading cause of death in the US for the last century with
resultant heart failure (HF) accounting for nearly 800,000 deaths per year. Despite substantial advancements in
clinically available interventions, the incidence of HF continues to rise with a staggering estimated economic…
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