grant
Novel pathways and mechanisms underlying disorders of platelet count and/or function
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Apr 2026Deadline 31 Jan 2033
NIHUS FederalResearch GrantFY2026AdhesionsAffectAffinityApproaches to preventionAreaArteriesAssayBioassayBiological AssayBiologyBleedingBlood Coagulation DisordersBlood Platelet CountBlood Platelet DisordersBlood Platelet NumberBlood PlateletsBlood VesselsCancersCardiac infarctionCell Communication and SignalingCell SignalingCirculationCoagulation DisorderCoagulopathyComplexDeep Vein ThrombosisDeep-Venous ThrombosisDefectDevelopmentDiagnosisDiseaseDisorderG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGoalsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHemorrhageHemostasisHemostatic functionHereditaryHumanIn VitroInheritedInjuryIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingKnowledgeLifeMalignant NeoplasmsMalignant TumorMarrow plateletMeasuresModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular StereochemistryMonitorMyocardial InfarctMyocardial InfarctionPathogenesisPathway interactionsPersonalized medical approachPhlebothrombosisPlatelet ActivationPlatelet CountPlatelet Count measurementPlatelet NumberPlateletsPrevention approachProductionReceptor ProteinRegulationRoleSightSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteThrombocytesThrombocytopathyThrombocytopeniaThrombopeniaThrombosisTransfusionVenousVenous ThrombosisVisionWorkbiological signal transductionbiomarker developmentbiomarker identificationbleeding disorderblood losscardiac infarctclotting disorderconformationconformationalconformational stateconformationallyconformationscoronary attackcoronary infarctcoronary infarctiondevelopmentalheart attackheart infarctheart infarctionidentification of biomarkersidentification of new biomarkersimprovedin vivoindividualized approachinjuriesinjury to the vasculaturemalignancymarker identificationneoplasm/cancernovelpathwaypersonalized approachplatelet diseaseplatelet disorderplatelet functionprecision approachreceptorsocial roletailored approachthromboembolic complicationsthrombosis complicationsthromboticthrombotic complicationsthrombotic diseasethrombotic disordervascularvascular injuryvisual function
Description preview
PROJECT SUMMARY
Our overall vision and long-term goal are to obtain a more complete understanding for how cellular signaling
pathways, in particular G proteins and integrin receptors, control platelet adhesion and plug formation in
hemostasis and thrombosis. Furthermore, we aim to elucidate aspects of the signaling machinery that function…
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