grant
Novel mitophagy regulatory mechanism in heart failure
Organization LOUISIANA STATE UNIV HSC SHREVEPORTLocation SHREVEPORT, UNITED STATESPosted 7 Jun 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AblationAdeno-Associated VirusesAgonistAssociated VirusesAutophagocytosisAutoregulationBiochemicalBioinformaticsCardiacCardiac Muscle CellsCardiac MyocytesCardiocyteCell BodyCellsComplexCorrelative StudyDataDependoparvovirusDependovirusDevelopmentDown-RegulationDysfunctionElongation FactorFibrosisFunctional disorderGene DeliveryGene ModifiedGeneticHeartHeart InjuriesHeart Muscle CellsHeart failureHeart myocyteHomeostasisHypertrophyImpairmentIn VitroInjuryIschemiaIschemic HeartIschemic Heart DiseaseIschemic myocardiumKO miceKnock-out MiceKnockout MiceLaboratoriesLigandsLightLiteratureMAP1 Microtubule-Associated ProteinMediatingMiceMice MammalsMicrotubule Associated Protein 1MitochondriaMolecularMurineMusMyocardial IschemiaMyocardial depressionMyocardial dysfunctionNull CellsNull LymphocytesNull MouseOrganellesPathogenesisPathologicPathway interactionsPatientsPhotoradiationPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyProcessProtein FamilyProteinsProteomicsPublishingReceptor ActivationReceptor ProteinReceptor-Interacting ProteinRegulationReporterReportingResearchRoleSatellite VirusesSerotypingSignal PathwayStressStructureTestingTherapeuticTransgenic MiceTranslationsUpregulationadeno associated virus groupantagonismantagonistautophagycardiac dysfunctioncardiac failurecardiac functioncardiac injurycardiac ischemiacardiomyocytecardioprotectantcardioprotectioncardioprotectiveconditional knock-outconditional knockoutcoronary ischemiadevelopmentalfunction of the heartgain of functiongene modificationgenetic approachgenetic strategygenetically modifiedheart dysfunctionheart functionheart ischemiain vivoin vivo Modelinjuriesinterdisciplinary approachknock-downknockdownloss of functionmitochondrialmouse modelmultidisciplinary approachmurine modelmyocardial ischemia/hypoxiamyocardium ischemianoveloverexpressoverexpressionpathophysiologypathwaypharmacologicpleiotropic effectpleiotropismpleiotropypressurepreventpreventingprotective effectreceptorreceptor functionresponsesigma-1 receptorsocial rolestemtranslation
Description preview
Project Summary:
Macro-autophagy and mitophagy (a mitochondria-specific form of autophagy) are constitutively active in the
heart and essential to maintaining cardiomyocyte survival under stress by removing potentially harmful proteins
and organelles. Extensive studies suggested the occurrence of macro-autophagy and mitophagy impairment
early in…
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