grant
Novel mechanisms of HIV-associated pulmonary vascular disease
Organization AUGUSTA UNIVERSITYLocation AUGUSTA, UNITED STATESPosted 20 Aug 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS preventionAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdoptive TransferAgingAmericanAnimal ModelAnimal Models and Related StudiesAnti-HIV PositivityAntibodiesAortaBlood VesselsBone Marrow GraftingBone Marrow TransplantBone Marrow TransplantationCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCardiac DiseasesCardiac DisordersCardiopulmonaryCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell Growth in NumberCell IsolationCell MultiplicationCell ProliferationCell SegregationCell SeparationCell Separation TechnologyCellsCellular ProliferationChronicChronic DiseaseChronic IllnessCirculationCo-cultureCocultivationCocultureCoculture TechniquesCollagenCor pulmonaleCultured CellsDataDepositDepositionDevelopmentDifferences between sexesDiffers between sexesDiseaseDisorderExposure toFemaleGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyHIVHIV PositiveHIV PositivityHIV PreventionHIV SeroconversionHIV SeropositivityHIV antibody positiveHIV diagnosisHIV-1HIV-IHIV/AIDS preventionHIV1HTLV-III SeroconversionHTLV-III SeropositivityHeart DiseasesHeart VascularHematopoieticHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1IndividualInterleukinsKnowledgeLAV-HTLV-IIILeiomyocyteLife ExpectancyLungLung DiseasesLung Respiratory SystemLung damageLymphadenopathy-Associated VirusMarrow TransplantationMeasuresMediatingMiceMice MammalsModern ManMolecularMurineMusOutcomePBMCPathologicPeripheral Blood Mononuclear CellPersonsPhenotypePopulationPrevalencePreventionProductionProphylactic treatmentProphylaxisProteinsPulmonary ArteryPulmonary DiseasesPulmonary DisorderPulmonary Heart DiseasePulmonary Heart DisorderPulmonary arterial remodelingPulmonary artery structureRNA SeqRNA sequencingRNAseqRecombinant DNA TechnologyReportingResearch SpecimenRight Ventricular HypertrophyRoleSex DifferencesSexual differencesSignal PathwaySmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSpecimenSystemSystolic PressureT-CellsT-LymphocyteT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTestingTimeTrans-Activation of Transcription ProteinTrans-Activator of Transcription of HIVTransactivating Regulatory ProteinVascular Smooth MuscleVentricularViralViral Gene ProductsViral Gene ProteinsViral ProteinsViremiaVirus-HIVWild Type Mouseaging associatedaging relatedantiretroviral therapyantiretroviral treatmentblood damagecardiopulmonary diseasecardiopulmonary disordercardiovascular disease riskcardiovascular disorder riskcell sortingchronic disordercirculatory systemdevelopmentaldisease of the lungdisorder of the lungdistal pulmonary artery remodelinggenetically engineeredheart disorderhemopoietichigh riskimpaired pulmonary vascularizationin vivoinhibitorlung arterial remodelinglung disorderlung injurylung vascular diseaselung vascular remodelingmalemodel of animalmouse modelmurine modelneutralizing antibodynew drug targetnew drug treatmentsnew druggable targetnew drugsnew markernew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel biomarkernovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel markernovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetoverexpressoverexpressionpharmacologicpromoterpromotorpulmonarypulmonary arterioles remodelingpulmonary artery remodelingpulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injurypulmonary vascular cell proliferationpulmonary vascular diseasepulmonary vascular disorderpulmonary vascular dysfunctionpulmonary vascular remodelingpulmonary vasculopathyright ventricle hypertrophyscRNA sequencingscRNA-seqsex based differencessex-dependent differencessex-related differencessex-specific differencessingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall pulmonary artery remodelingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstat Proteinthymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingvascularvascular smooth muscle cell proliferationviraemiaviral sepsisvirus proteinvirusemiawildtype mouse♀♂
Description preview
PROJECT SUMMARY
Thanks to the advent of combination antiretroviral therapy (cART), life expectancy has dramatically increased in
people with HIV (PWH) and the spectrum of diseases related to HIV has shifted towards non-infectious chronic
illnesses including cardiopulmonary disorders. Pulmonary vascular disease (PVD) is amongst the most
devastating…
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