grant
Novel Markers for Disease Outcome in Breast Cancer
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAdventitial CellAffectAfricanAfrican AmericanAfrican American FemalesAfrican American WomenAfrican FemalesAfrican WomenAfrican ancestryAfrican descentAfro AmericanAfroamericanAmericanArchitectureAssay for Transposase-Accessible Chromatin using sequencingAwardBiologic CharacteristicBiologicalBiological CharacteristicsBiologyBlood SampleBlood specimenBody TissuesBreast CancerBreast Cancer PatientBreast Cancer Risk FactorBreast NeoplasmsBreast TissueBreast Tumor PatientBreast TumorsCCRCancer BiologyCancer Research ProgramsCancer Research ProjectCancerousCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCharacteristicsChromatinChronicClinicalClinical ResearchClinical StudyDCEGDNA MethylationDNA copy numberData SetDendritic CellsDevelopmentDiabetes MellitusDigestionDiseaseDisease OutcomeDisorderDivision of Cancer Epidemiology and GeneticsEngineering / ArchitectureEnvironmentEnvironmental ExposureEpithelial CellsEpitheliumEthnic OriginEthnicityEuropeanEuropean ancestryExcess MortalityExhibitsExpression SignatureFibroblastsFreezingGene Expression ProfileGeneticGenomicsHeterogeneityHormonalImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologic DiseasesImmunologicalImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologicallyImmunologicsImpairmentIndividuals from minorityIndividuals of minorityInflammationIntracellular Communication and SignalingInvestigationInvestigatorsKenyaKnowledgeLaboratoriesMalignant Breast NeoplasmMammary CancerMammary Gland ParenchymaMammary Gland TissueMammary NeoplasmsManuscriptsMeasuresMediatorMinority GroupsMinority PeopleMinority PopulationMinority individualMolecularMyelogenousMyeloidNeighborhoodsNucleusObesityOutcomeOxidation-ReductionPathologyPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPericapillary CellPericytesPerivascular CellPopulation GroupPreventionProcessProteomeProteomicsProtocolProtocols documentationPublicationsRNA SeqRNA sequencingRNAseqRaceRacesRedoxRegulatory T-LymphocyteReproductive FactorsReproductive HistoryReproductive History EpidemiologyReproductive IssuesResearch PersonnelResearchersResolutionRisk FactorsRouget CellsScheduleScientific PublicationSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSocial EnvironmentSocial isolationSocial supportStressStressful EventStromal CellsSurvey InstrumentSurveysSystemT-CellsT-LymphocyteTM-MKRTechnologyTissue SampleTissuesTregTumor BiologyTumor CellTumor MarkersTumor TissueValidationVascular Endothelial CellVeiled CellsVulnerable PopulationsWomanadiposityaggressive breast canceranti-tumor immune responseassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiologicbiological signal transductionbiomarker identificationbreast cancer riskbreast densitycancer disparitycancer health disparitycancer microenvironmentcancer surgerycancer-related health disparitycell typeclinical significanceclinically significantco-morbidco-morbiditycohortcomorbiditycorpulencedata pipelinedeprivationdevelopmentaldiabetesdigitaldigital pathologydiscrimination based on ethnicitydiscrimination based on racediscrimination due to racedisease riskdisorder riskdisparity in cancerdisparity in healthethnic discriminationethnicity-based discriminationexperienceexperienced discriminationgene expression patterngene expression signaturegene signaturesgenetic signaturegenome scalegenome sequencinggenome-widegenomewidehealth disparityhost responseidentification of biomarkersidentification of new biomarkersimmune microenvironmentimmune system responseimmunoresponseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentindividuals with breast cancerinflammation markerinflammatory markerinsightmalignant breast tumormammary tumormarker identificationmetabolomemetabonomemultiomicsmultiple omicsneoplastic cellnew markernovel biomarkernovel markeroxidation reduction reactionpanomicspathwaypatient oriented outcomespatients with breast cancerperceived discriminationperceived stressperception of discriminationperception of stressperson with breast cancerpublic health interventionrace discriminationrace-based discriminationrace-related discriminationracialracial backgroundracial discriminationracial originregulatory T-cellsresolutionssNuc-Seqself-reported discriminationself-reported stresssingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial climatesocial contextsocial support networksocial vulnerabilitysocioenvironmentsocioenvironmentalspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstress perceptionstressful experiencestressful life eventstressful life experiencestressorsurvival outcomesurvival predictionsystemic inflammationsystemic inflammatory responsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetranscriptional profiletranscriptional signaturetranscriptome profilingtranscriptome sequencingtranscriptomic profilingtranscriptomic sequencingtranscriptomicstumortumor biomarkertumor immune microenvironmenttumor microenvironmenttumor specific biomarkertumor-immune system interactionstumorigenicvalidationsvulnerable groupvulnerable individualvulnerable people
Description preview
Project 1: The mechanisms through which chronic stressors may be associated with tumor biologic characteristics, immune response, and health disparities remain insufficiently understood. Hence, we investigated the proteomic, transcriptomic, and genomic effects associated with multilevel chronic stressors (perceived stress, perceived inadequate…
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