grant
Novel immunoregulatory mechanisms that modulate myeloid trained immunity following transplantation
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 18 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AccelerationAcuteAd vectorAdenoviral VectorAdenovirus VectorAdoptive TransferAlloantigenAllogenicAllograftingAntigen PresentationAntigensAutoimmune StatusAutoimmunityBacteriaBiologyBiometricsBiometryBiopsyBiostatisticsBlood monocyteBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD47CD47 AntigenCD47 GlycoproteinCD47 geneCardiac TransplantationCategoriesCell BodyCell Communication and SignalingCell SignalingCellsCellular biologyChronicClinicalCo-cultureCocultivationCocultureCoculture TechniquesCollaborationsConsultDataDevelopmentExposure toExpression SignatureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene Expression ProfileGoalsGraft RejectionGraft SurvivalGrafting ProcedureHeart GraftingHeart TransplantationHumanIMiDImmuneImmune modulatory therapeuticImmune responseImmune systemImmunesImmunityImmunizationImmunomodulationImmunosuppressantsImmunosuppressive AgentsImmunosuppressive drugImmunosuppressive treatmentIn VitroInflammationInnate Immune SystemInnate ImmunityIntegrin-Associated ProteinIntracellular Communication and SignalingKO miceKidney GraftingKidney TransplantationKidney TransplantsKnock-outKnock-out MiceKnockoutKnockout MiceLaboratoriesLicensingLigandsMER6MacrophageMarrow monocyteMemoryMethodsMiceMice MammalsModelingModern ManMurineMusMyelogenousMyeloidMyeloid CellsMφNRP2 ProteinNative ImmunityNatural ImmunityNetwork AnalysisNeuropilin-2Non-Specific ImmunityNonspecific ImmunityNpn-2 ProteinNull MouseOrgan TransplantationOrgan TransplantsPathway AnalysisPhagocytosisPositionPositioning AttributeProteinsReceptor ProteinRecombinant ProteinsRegulationRenal GraftingRenal TransplantationRenal TransplantsRoleSHPS-1 proteinSIRPalpha1SemaphorinsSignal InductionSignal TransductionSignal Transduction SystemsSignalingSplenocyteSurface Antigen Identified by Monoclonal Antibody 1D8SystemT-Cell ActivationT-CellsT-LymphocyteT4 CellsT4 LymphocytesTamoxifenTestingTherapeuticTissuesTrainingTransgenic MiceTransplant RecipientsTransplant RejectionTransplantationTransplantation RejectionTumor CellVirusactivate T cellsadaptive immunityadeno vectoradenovectoralloimmunitybiological signal transductioncardiac allograftcardiac graftcell biologyconsultsdesigndesigningdevelopmentaldrug candidateexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygene expression patterngene expression signaturegraft functionheart allograftheart transplanthost responseimmune modulating agentsimmune modulating drugimmune modulating therapeuticsimmune modulationimmune modulatory agentsimmune modulatory drugsimmune regulationimmune suppressive agentimmune suppressorimmune system responseimmunogenimmunologic reactivity controlimmunomodulating agentsimmunomodulating drugsimmunomodulator agentimmunomodulator drugimmunomodulator medicationimmunomodulator prodrugimmunomodulator therapeuticimmunomodulatoryimmunomodulatory agentsimmunomodulatory drugsimmunomodulatory therapeuticsimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive substanceimmunosuppressorin vivoinfection recurrenceisoimmunitykidney txmonocytemouse modelmultiomicsmultiple omicsmurine modelneoplastic cellnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetorgan allograftorgan graftorgan xenograftosmotic minipumpoverexpressoverexpressionpanomicspathogenpost-transplantpost-transplantationposttransplantposttransplantationpreventpreventingreceptorrecurrent infectionrecurring infectionresponsescRNA sequencingscRNA-seqsignal-regulatory proteinsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesupport networkthymus derived lymphocytetooltranscriptional profiletranscriptional signaturetranscriptomicstransplanttransplant patient
Description preview
Project Summary/Abstract
The immune system can be categorized into innate and adaptive immunity. Innate immune cells detect and
respond according to danger associated signals and initiate a coordinated antigen-specific response by the
adaptive system to eliminate threats such as viruses, bacteria and tumor cells. Immunosuppressive drugs
inhibit…
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