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Novel imaging genetic biomarkers for sporadic frontotemporal dementia through machine learning
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 15 Mar 2021Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAD related dementiaADRDAccelerationAgeAge of OnsetAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAmentiaAtrophicAtrophyBehavioralBiologicalBiological MarkersBiometricsBiometryBiostatisticsBrain MappingCaliforniaCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemClassificationClinicalClinical ResearchClinical StudyClinical TrialsClinical Trials DesignCognitive agingComplexComputer ModelsComputerized ModelsDataData SetDegenerative Neurologic DisordersDementiaDevelopmentDiagnosisDiagnosticDifferential DiagnosisDiscriminant AnalysesDiscriminant AnalysisDiseaseDisorderEarly DiagnosisEnvironmentEpidemiologistEpidemiologyFTD dementiaFTLDFosteringFrontal Temporal DementiaFrontal Temporal Lobar DegenerationFrontotemporal DementiaFrontotemporal Lobar DegenerationsFrontotemporal variety lobar degenerationGene variantGenesGeneticGenetic MarkersGenetic ModelsGenetic ResearchGenetic RiskGenotypeGoalsHeart VascularHereditaryImageImmuneImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIncidenceIndividualInheritedInternationalIrisK01 AwardK01 MechanismK01 ProgramKnowledgeMR ImagingMR TomographyMRIMRIsMT-bound tauMachine LearningMagnetic Resonance ImagingMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMentored Research Scientist Development AwardMentored Training AwardMentorsMentorshipMethodologyMethodsMissionModelingMultimodal ImagingNMR ImagingNMR TomographyNational Institutes of HealthNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologistNeuron DegenerationNuclear Magnetic Resonance ImagingOutcomePathway interactionsPatientsPatternPerformancePhenotypePostdocPostdoctoral FellowPredicting RiskPrimary Senile Degenerative DementiaPrognosisR-Series Research ProjectsR01 MechanismR01 ProgramResearchResearch AssociateResearch GrantsResearch MethodologyResearch MethodsResearch Project GrantsResearch ProjectsResearch Scientist Development AwardRiskRoleSan FranciscoScientistSocial BehaviorStratificationSubgroupSystematicsTauopathiesTechniquesTemporal LobeTherapeuticTherapeutic Clinical TrialTimeTrainingTranslatingUnited States National Institutes of HealthUniversitiesValidationWorkZeugmatographyaccurate diagnosisage associatedage correlatedage dependentage linkedage relatedage specificagesallelic variantalzheimer riskbio-markersbiologicbiologic markerbiomarkerbiomarker developmentcardiovascular disordercareercirculatory systemclinical developmentclinical heterogeneityclinical subtypescohortcomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdementia riskdevelopmentaldiagnostic toolearly detectionepidemiologicepidemiologicalexperienceforecasting riskfront temporal dementiafrontal cortexfrontal lobefrontal lobe dementiafrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobe degeneration associated with dementiagene biomarkergene expression biomarkergene markergene signature biomarkergenetic biomarkergenetic variantgenomic varianthazardhigh riskimagingimaging biomarkerimaging geneticsimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedindividualized strategiesinnovateinnovationinnovativelanguage abilitylanguage skillsmachine based learningmicrotubule bound taumicrotubule-bound taumulti-modal datamulti-modal datasetsmulti-modal imagingmulti-modalitymulti-modality imagingmultimodal datamultimodal datasetsmultimodalitymultimodality imagingneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurodegenerative illnessneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropathologicneuropathologic tauneuropathologicalneuropathological tauneuropathologynovelpathwaypatient centeredpatient orientedpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespersonalization of treatmentpersonalized medicinepersonalized strategiespersonalized therapypersonalized treatmentpleiotropic effectpleiotropismpleiotropypolygenetic risk scorespolygenic risk scorepopulation basedpost-docpost-doctoralpost-doctoral traineepredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive biological markerpredictive biomarkerspredictive markerpredictive modelingpredictive molecular biomarkerpredictive riskpredicts riskprimary degenerative dementiaprofessorprognostic toolprogramsrecruitresearch and methodsresearch associatesrisk factor for dementiarisk for dementiarisk predictionrisk predictionssenile dementia of the Alzheimer typeskillssocial rolesociobehaviorsociobehavioralstatisticssymptomatologytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytemporal cortextoolvalidationsτ Proteins
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Project Summary
This is an application for a K01 award for Dr. Iris Broce-Diaz, a neuroimaging genetics postdoctoral fellow at the
University of California, San Diego and University of California, San Francisco. Dr. Broce-Diaz is establishing
herself as a young imaging geneticist conducting clinical research on neurodegenerative disease. This K01…
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