grant
Novel Humanized Mouse Models For Engraftment of Tissue-Specific Human Macrophage Population
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 15 Jul 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AD associated neurodegenerationAD dementiaAD neurodegenerationAIDS VirusAPP-PS1APP/PS1AccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdaptive Immune SystemAlzheimer Type DementiaAlzheimer associated neurodegenerationAlzheimer disease dementiaAlzheimer related neurodegenerationAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease associated neurodegenerationAlzheimer's disease related neurodegenerationAlzheimers DementiaAmyloid (Aβ) plaquesAmyloid PlaquesAnimal ModelAnimal Models and Related StudiesAutoregulationBasic ResearchBasic ScienceBiologyBirthBody TissuesBrainBrain Nervous SystemCD34CD34 geneCSF1CSF1 geneCell BodyCellsCollaborationsCommunitiesCord BloodDataDevelopmentDiseaseDisorderDisseminated SclerosisEmbryoEmbryonicEncephalonEngraftmentEnhancer ElementsEvaluationGenerationsGeneticGenetic Enhancer ElementGoalsHIVHIV InfectionsHPCA1HTLV-III InfectionsHTLV-III-LAV InfectionsHeartHomeostasisHortega cellHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsImmuneImmune responseImmune systemImmunesImmunodeficient MouseImmunologyImpairmentInflammatoryInvestigationKidneyKidney Urinary SystemKnock-outKnockoutLAV-HTLV-IIILiverLungLung Respiratory SystemLymphadenopathy-Associated VirusMCSFMGC31930MacrophageMediatingMiceMice MammalsMicrogliaModelingModern ManModificationMultiple SclerosisMurineMusMyelogenousMyeloidMyeloid CellsMφNational Institutes of HealthNerve DegenerationNeuritic PlaquesNeuron DegenerationPSEN1ParturitionPathogenesisPeritoneumPhysiological HomeostasisPopulationPrimary Senile Degenerative DementiaProtein PrecursorsR-Series Research ProjectsR01 MechanismR01 ProgramReceptor GeneRegulatory ElementReportingReproducibilityResearchResearch GrantsResearch Project GrantsResearch ProjectsResearch ResourcesResourcesRoleS182 proteinSenile PlaquesStudy modelsTestingThe Jackson LaboratoryTissue ModelTissuesTransgenic OrganismsUmbilical Cord BloodUnited States National Institutes of HealthValidationViral PathogenesisVirus-HIVWorkYolk Sacacquired immune systemamyloid beta plaqueamyloid-b plaqueanimal model developmentaβ plaquescored plaquecytokinedevelopmentaldiffuse plaqueenhancer sequencefetal cord bloodgenetic enhancer sequencegitter cellhepatic body systemhepatic organ systemhost responsehuman diseasehuman tissuehumanized micehumanized mousehypoimmunityimmune deficiencyimmune system responseimmunodeficiencyimmunoresponseimprovedin vivoinsular sclerosisinterestmedical collegemedical schoolsmesogliamicroglial cellmicrogliocytemodel of animalmouse developmentmouse modelmultidisciplinarymurine modelneural degenerationneural inflammationneurodegenerationneurodegenerativeneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationnovelperivascular glial cellpresenilin 1 proteinpresenilin-1primary degenerative dementiaprogenitorprogramsradiation resistantradioresistantrenalresistant to radiationresponseschool of medicinesenile dementia of the Alzheimer typesocial roletransgenicvalidationsvirus pathogenesisvitelline sac
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Description preview
Tissue resident macrophages are derived from embryonic yolk sac progenitors, develop prior to birth, are long-
lived and radioresistant, and have critical functions in maintaining tissue homeostasis and in the pathogenesis
of many human diseases that are of broad interest to NIH. This proposal is to build cutting-edge humanized
mouse resources…
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