grant
Novel Approach to Hepatocellular Carcinoma Treatment through Enhanced ER Stress
Organization UNIVERSITY OF TEXAS HLTH SCIENCE CENTERLocation SAN ANTONIO, UNITED STATESPosted 14 Mar 2025Deadline 13 Mar 2030
NIHUS FederalResearch GrantFY2025Acid LipaseAffectApoptosisApoptosis PathwayAssayAutoregulationBindingBioassayBiochemicalBioinformaticsBiologicalBiological AssayBody TissuesCRISPRCRISPR/Cas systemCancer BiologyCancer CauseCancer CenterCancer EtiologyCancersCarcinoma CellCatchment AreaCell BodyCell DeathCell SurvivalCell ViabilityCell modelCellsCellular modelCessation of lifeClustered Regularly Interspaced Short Palindromic RepeatsCommunicationDNA Molecular BiologyDataDeathDevelopmentDiagnosisDrug KineticsDrugsER stressEndoplasmic ReticulumEnvironmentErgastoplasmEthnic OriginEthnicityFutureGeneralized GrowthGenetic ScreeningGrowthHealthHepatic CancerHepatocarcinomaHepatocarcinoma modelHepatocellular CarcinomaHepatocellular cancerHepatomaHeterograftHeterologous TransplantationHispanic PopulationsHispanic groupHispanic individualHispanic peopleHispanicsHomeostasisHumanIn VitroIncidenceInduction of ApoptosisInnovative TherapyIntratumoral heterogeneityKnock-outKnockoutLearningLipaseLiverLiver Cells CarcinomaMalignant CellMalignant Epithelial CellMalignant NeoplasmsMalignant TumorMalignant neoplasm of liverMedicationMentorsMethodsMicroscopyModelingModern ManMolecularMolecular BiologyMolecular InteractionNCI-Designated Cancer CenterNamesNormal CellOralOrganellesOrganoidsOxidative StressPDX modelPathway interactionsPatient derived xenograftPatientsPh D studentPh D. studentPh. D. studentPh.D studentPh.D. studentPhD studentPhD. studentPharmaceutical PreparationsPharmacokineticsPhysiciansPhysiological HomeostasisPilot ProjectsPlayPre-Clinical ModelPreclinical ModelsPreparationPrimary carcinoma of the liver cellsPrognosisProgrammed Cell DeathPropertyProtein BiosynthesisProteinsProteomicsPublishingResearchResearch ResourcesResourcesRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleScheduleScientistSouth TexasSurveillance ProgramSurvival RateSystemTestingTherapeuticTissue GrowthTissuesTrainingTranslationsTransmissionTreatment EfficacyTriacylglycerol HydrolaseTriacylglycerol LipaseTriacylglycerol acylhydrolaseTributyrinaseTriglyceridaseTriglyceride LipaseTriolean HydrolaseUnited StatesWritingXenograftXenograft ModelXenograft procedureXenotransplantationbiologiccancer cellcareerchemotherapyclinical translationclinically translatablecombatdetermine efficacydevelopmentaldoctoral studentdrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy testingendoplasmic reticulum stressevaluate efficacyexamine efficacyfirst in manfirst-in-humangenome scalegenome-widegenomewidehepatic body systemhepatic organ systemhepatocellular carcinoma cancer modelhepatocellular carcinoma modelheterogeneity in tumorshuman studyin vivoin vivo Modelinnovateinnovationinnovativeintervention efficacyintra-tumoral heterogeneityintratumor heterogeneityknock-downknockdownliver cancerliver cancer modelliver carcinomaliver malignancymalignancymalignant liver tumormolecular imagingmolecule imagingmortalitynamenamednamingnecrocytosisneoplasm/cancernew approachesnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel approachesnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetontogenypathwaypatient derived xenograft modelpilot studypre-clinicalpreclinicalpreparationsprotein foldingprotein homeostasisprotein synthesisproteostasisreconstitutereconstitutionresponseshRNAshort hairpin RNAsmall hairpin RNAsmall moleculesocial rolestudent mentoringstudent-led learningtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic effectivenesstherapeutic efficacytherapeutic evaluationtherapeutic testingtherapy efficacytooltranscriptomicstranslationtransmission processtributyrasetumor heterogeneityxeno-transplantxeno-transplantationxenograft transplant modelxenotransplant model
Description preview
Project Summary
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death in the world and is the fastest
growing cause of liver cancer death in the United States. The prognosis of advanced HCC is exceedingly dismal,
with a median survival rate of about 10 months. Despite the administration of several surveillance programs to…
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