grant
Novel antiviral mechanisms of the interferon system
Organization UNIVERSITY OF KENTUCKYLocation LEXINGTON, UNITED STATESPosted 25 May 2022Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase5'-AMP-activated protein kinaseAMP-activated kinaseAMP-activated protein kinaseAMPK enzymeAPF-1ATP-Dependent Proteolysis Factor 1AblationAddressAlveolar MacrophagesAnti-viral ResponseAnti-viral TherapyAutophagocytosisBiochemicalBone MarrowBone Marrow Reticuloendothelial SystemC-terminalCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCellsChemicalsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexCoronaviridaeCoronavirusDendritic CellsDiseaseDisorderEmbryoEmbryonicEngineeringFibroblastsFutureGene TranscriptionGenesGeneticGenetic ScreeningGenetic TranscriptionGoalsHMG CoA reductase (NADPH) kinaseHMG CoA reductase kinaseHMG coenzyme A reductase (NADPH) kinaseHMG-20HPIV3HSVHemadsorption Virus 1Hemagglutinating Virus of JapanHerpes Simplex VirusHerpes labialis VirusHerpesviridaeHerpesvirusesHigh Mobility Protein 20Host DefenseHumanHuman Parainfluenza Virus 3IFNInfluenza AInfluenza A virusInfluenza VirusInfluenza Viruses Type AInfluenzavirus AInterferonsKO miceKinasesKnock-out MiceKnockout MiceKnowledgeLibrariesLife CycleLife Cycle StagesLungLung Respiratory SystemMapsMediatingMiceMice MammalsMicroscopicModelingModern ManMolecularMorbidityMorbidity - disease rateMurineMusMutateNatureNull MouseOrthocoronavirinaeOrthomyxovirus Type AOrthopneumovirusPara-Influenza Virus Type 3ParamyxoviridaeParamyxovirusPathogenesisPathway interactionsPattern recognition receptorPhosphotransferase GenePhosphotransferasesPneumoviridaePneumovirinaePneumovirusProteinsPublishingPulmonary MacrophagesRNA ExpressionRegulationReportingRespiratory infectious agentRespiratory tract pathogenRoleSendai virusSeriesSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSimplexvirusSystemTestingTherapeuticTimeTranscriptionTransphosphorylasesType A InfluenzaUbiquitilationUbiquitinUbiquitinationUbiquitinoylationVeiled CellsViralViral ActivityViral BurdenViral DiseasesViral FunctionViral LoadViral Load resultViral PathogenesisViral PhysiologyViral Respiratory Tract InfectionVirusVirus DiseasesVirus ReplicationWorkautophagycorona virusdomain mappinggenetic approachgenetic strategyherpes virushuman diseasehydroxymethylglutaryl-CoA-reductase kinasein vivoinfluenzavirusinhibition of autophagyinnovateinnovationinnovativelife coursemortalitynew approachesnovelnovel approachesnovel strategiesnovel strategyparainfluenza virus type 3pathwaypreventpreventingrespiratoryrespiratory pathogenrespiratory virusresponseshRNAshort hairpin RNAside effectsmall hairpin RNAsocial roletoolubiquinationubiquitin conjugationviral detectionviral infectionviral infectious disease treatmentviral multiplicationviral replicationviral respiratory infectionvirus detectionvirus host interactionvirus infectionvirus multiplicationvirus pathogenesisvirus-induced disease
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Project Summary/Abstract
The respiratory viruses, including coronaviruses, the paramyxo/pneumoviruses, and the influenza virus, cause
lethal human diseases, and the treatment options are limited or non-existent. The interferon (IFN) system is the
first line of host defense against a wide range of viral infections. Viral infection is sensed by the…
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