grant
Non-B DNA structure discovery and function assessment using nanopore translocation times
Organization UNIVERSITY OF CONNECTICUT STORRSLocation STORRS-MANSFIELD, UNITED STATESPosted 20 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20253rd generation sequencingAffectB Form DNAB-DNABenchmarkingBest Practice AnalysisBiological FunctionBiological ProcessCancer InductionCell BodyCellsCentromereComputational toolkitComputer Software ToolsComputing MethodologiesDNADNA StructureDataDeoxyribonucleic AcidDiseaseDisorderGenetic DiseasesHaplotypesHumanIndividualKnowledgeLocationMedicalModern ManMolecularNon-Polyadenylated RNAPerformancePhenotypeProspective StudiesProtocolProtocols documentationRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqResearchResearch DesignRibonucleic AcidRight-Handed DNARoleSamplingSeriesSiteSoftware ToolsSpecific qualifier valueSpecificitySpecifiedSpeedStructureStudy TypeTelomeraseThird Generation SequencingTimeValidationbasebasesbenchmarkbiobankbiorepositorycarcinogenesisclinical relevanceclinically relevantcomputational methodologycomputational methodscomputational toolboxcomputational toolscomputational toolsetcomputer based methodcomputer based predictioncomputer methodscomputerized toolscomputing methodcostgenetic conditiongenetic disorderin siliconano porenanoporenanopore based sequencingnanopore long read seqnanopore long-read sequencingnanopore seqnanopore sequencingnanopore-based long-read sequencingnovelopen source toolopen source toolkitpredictive modelingpromoterpromotorsequencing platformsocial rolesoftware toolkitstatisticsstudy designtooltraittranscriptome sequencingtranscriptomic sequencingvalidations
Description preview
Abstract
The canonical double helical structure of DNA (B-DNA) allows for stability and high-fidelity replication, but
emerging evidence suggests an increasingly important role for non-canonical (or non-B) DNA structures in
the cell. Non-B DNA structures have been (a) implicated in genetic disorders and carcinogenesis due to their
increased…
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