grant
Nitric Oxide and Endothelial Function in Patients with Malaria
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldASCVDAccelerationAdultAdult HumanAmericanAmino AcidsAnimal ModelAnimal Models and Related StudiesArginineArteriesAtherosclerosisAtherosclerotic Cardiovascular DiseaseAwardB-globinBH4BP reductionBPH4BabesiaBabesia infectionBabesia parasite infectionBabesiosisBasic ResearchBasic ScienceBindingBioavailabilityBiochemicalBiological AvailabilityBiologyBloodBlood DiseasesBlood PressureBlood Reticuloendothelial SystemBlood VesselsBlood erythrocyteCambodianCanine SpeciesCanis familiarisCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCaringCell Communication and SignalingCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCessation of lifeChargeChemicalsChildChild YouthChildren (0-21)ChronicCirculationClinicalClinical ProtocolsClinical ResearchClinical StudyCollaborationsCollectionCommentCommentaryComplexCryo-electron MicroscopyCryoelectron MicroscopyCrystallographiesCrystallographyDNA mutationDeathDevelopmentDiffusionDiseaseDisorderDogsDogs MammalsDrugsDysfunctionEDRF SynthaseENOSEditorial CommentElectron CryomicroscopyEndogenous Nitrate VasodilatorEndothelial CellsEndothelial Nitric Oxide SynthaseEndotheliumEndothelium-Derived Growth Factor SynthaseEndothelium-Derived Nitric OxideErythrocytesErythrocyticEuropeExerciseExhibitsFoundationsFunctional disorderFundingGene DeletionGene InactivationGene ProteinsGene SilencingGene variantGenesGenetic ChangeGenetic DiversityGenetic VariationGenetic defectGenetic mutationGenomeGenomicsGlobinGlutamic AcidGoalsGrantGripsGroups at riskGuanylyl Cyclase-Activating Factor SynthaseH4BH4biopterinHandHb SS diseaseHbASHbSS diseaseHealthHeart VascularHematologic DiseasesHematological DiseaseHematological DisorderHemoglobinHemoglobin H DiseaseHemoglobin SHemoglobin S DiseaseHemoglobin sickle cell diseaseHemoglobin sickle cell disorderHereditaryHospital AdmissionHospitalizationHumanHygieneImpairmentIndividualInhalationInhalingInheritedInstitutionInternal MedicineInterruptionIntracellular Communication and SignalingIntravenousJournalsKnowledgeL-ArginineL-Glutamic AcidL-ValineLeadLearningLeiomyocyteLibrariesLifeLiquid substanceLung DiseasesMagazineMalariaMaliManuscriptsMarrow erythrocyteMeasuresMedicationMedicineMetabolicModelingModern ManMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMolecular VaccinesMononitrogen MonoxideMutationNHLBINIAIDNIDDKNO SynthaseNOS3NOS3 geneNational Heart, Lung, and Blood InstituteNational Institute of Allergy and Infectious DiseaseNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthNitric OxideNitric Oxide SynthaseNitric Oxide Synthase 3Nitric Oxide Synthetase InhibitorNitric-Oxide SynthetaseNitrogen MonoxideNitrogen ProtoxideOrganOrthostasisPaludismParasitesParasitologyPathogenesisPatientsPb elementPeer ReviewPeople at riskPeptidesPerfusionPersonsPersons at riskPharmaceutical PreparationsPhenotypePhysiologicPhysiologic AvailabilityPhysiologicalPhysiologyPhysiopathologyPiroplasmaPiroplasmosisPlasmodium InfectionsPolymersPopulationPopulations at RiskPositionPositioning AttributeProgenitor Cell TransplantationProtein Gene ProductsProteinsPublicationsPublished CommentPublishingPulmonary DiseasesPulmonary DisorderRed Blood CellsRed CellRegulationRenal Blood FlowResearchResuscitationRoleScientific PublicationShapesSickle CellSickle Cell AnemiaSickle Cell TraitSickle HemoglobinSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSocietiesSpecificityStem Cell TransplantationStem cell transplantStimulusStructureTHBPTestingTherapeuticTick-Borne DiseasesTranslatingTrioxopurineTropical MedicineType III nitric oxide synthaseUnited StatesUnited States National Institutes of HealthUric AcidValineVariantVariationVascular DiseasesVascular DisorderVascular EndotheliumVascular Smooth MuscleVasodilatationVasodilationVasorelaxationViewpointWorkWritingZoonosesZoonoticZoonotic Infectionadulthoodallelic variantalpha Globinalpha-Thalassemiaaminoacidatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebeta Globinbiological signal transductionblood corpusclesblood disorderblood pressure reductionblood vessel disordercaninecirculatory systemclinical centerclinical investigationcofactorconferenceconventioncost effective therapycost effective treatmentcryo-EMcryoEMcryogenic electron microscopydesigndesigningdevelopmentaldiffuseddiffusesdiffusingdiffusionsdisease of the lungdisease riskdisorder of the lungdisorder riskdomestic dogdrug repositioningdrug repurposingdrug/agentendothelial cell derived relaxing factorendothelial dysfunctionessaysexperimentexperimental researchexperimental studyexperimentsfluidgene deletion mutationgenetic variantgenome mutationgenomic variantglobal healthgrasphandsheavy metal Pbheavy metal leadhemoglobin polymerimprovedin vivoinfected with Babesiainhibitorinnovateinnovationinnovativeintercellular communicationinterestkidsknock-downknockdownliquidlower BPlower blood pressurelowers blood pressurelung disorderlung functionmodel of animalmodel-based simulationmodels and simulationmolecular diagnosticsmolecular modelingnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnitric oxide synthase inhibitornovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachp-Globinpathophysiologypeptide mimeticpeptide mimicpeptidomimeticspoint-of-care diagnosticspolymerpolymericpolymerizationprogenitor transplantationpulmonary functionreduce BPreduce blood pressurereduction in BPreduction in blood pressurerenal arteryrepurposing agentrepurposing medicationresponsescaffoldscaffoldingsickle RBCsickle cell diseasesickle cell disordersickle diseasesickle erythrocytesickle red blood cellsicklemiasimulationsocial rolestem and progenitor cell transplantationssummitsymposiasymposiumtetrahydrobiopterintick-borne illnesstickborne diseasetickborne illnesstranscriptional silencingtreatment centertrendvascularvascular constrictionvascular dysfunctionvasculopathyvasoconstrictionvirtualyoungsterα-globinα-thalassemiaβ-globin
Description preview
Impaired nitric oxide synthase-dependent vasodilation is a common hallmark of infectious, inherited, and metabolic vascular diseases ranging from malaria to atherosclerosis. Efforts to restore nitric oxide (NO) signaling have been limited by an incomplete understanding of NO regulation in human arteries. We discovered that humans express both…
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