grant
NHGRI/DIR Bioinformatics and Scientific Programming Core
Organization NATIONAL HUMAN GENOME RESEARCH INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025AD/HDADHDAML1AMLCR1ATAC sequencingATAC-seqATACseqAddressAllelesAllelomorphsArchivesAreaAssay for Transposase-Accessible Chromatin using sequencingAttention deficit hyperactivity disorderAutopsyB cell receptorB-Cell Antigen ReceptorBindingBioinformaticsBiological MarkersBlood PlateletsBrachydanio rerioBrothersCBFA2CBFB-MYH11CBFbeta-MYH11CBFbeta-MYH11 fusion proteinCanine SpeciesCanis familiarisChIP SequencingChIP-seqChIPseqChild CareChromatinClinical DataClinical ResearchClinical StudyCollaborationsCommunitiesComputational toolkitComputer AnalysisComputer softwareDNADNA MethylationDNA TherapyDNA mutationDanio rerioDataData AnalysesData AnalysisData BasesData CollectionData SetDatabasesDeoxyribonucleic AcidDevelopmentDiagnosisDiseaseDisorderDogsDogs MammalsEducationEducational aspectsFamilial Platelet DisorderFrequenciesGene ExpressionGene TranscriptionGene Transfer ClinicalGenesGenetic ChangeGenetic DiseasesGenetic InterventionGenetic TranscriptionGenetic defectGenetic mutationGenomeGenomic SegmentGenomicsGoalsHaplotypesHereditaryHeritabilityHermanski-Pudlak SyndromeHermansky Pudlak syndromeHistocompatibilityHistoryIndividualInheritedInvestigatorsKI miceKnock-in MouseLaboratoriesLupus Erythematosus DisseminatusMaintenanceMapsMarrow plateletMetabolic DiseasesMetabolic DisorderMiceMice MammalsMitochondrial DiseasesMitochondrial DisordersMnemiopsisModalityModelingMolecular InteractionMurineMusMutationMyeloid DiseaseMyeloid MalignancyMyeloid NeoplasmMyeloid TumorMyeloproliferative DisordersMyeloproliferative TumorsMyeloproliferative diseaseNHGRINational Center for Human Genome ResearchNational Human Genome Research InstituteNerve CellsNerve UnitNeural CellNeurocyteNeuronsObese MiceObesityPEBP2A2PEBP2aBParentsPartner in relationshipPatientsPhenotypePlateletsPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderProteomePuericultureRNA ExpressionRNA SeqRNA sequencingRNAseqRUNX1RUNX1 geneRecording of previous eventsReportingResearchResearch PersonnelResearch SupportResearchersRetrievalSLESamplingSelection BiasSicca SyndromeSisterSjogren's DiseaseSjogren's SyndromeSjogrensSjögren SyndromeSoftwareSurvey InstrumentSurveysSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusT memory cellT-CellsT-LymphocyteThesaurismosisThrombocytesTissue CompatibilityTranscriptionVariantVariationYouthYouth 10-21Zebra DanioZebra FishZebrafishadiposityassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbehavior studybehavioral studybio-markersbiologic markerbiomarkerbrain tissuecaninechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingclinical outcome assessmentcohortcomputational analysescomputational analysiscomputational resourcescomputational toolboxcomputational toolscomputational toolsetcomputer analysescomputerized toolscomputing resourcescorpulencedata basedata interpretationdata portaldata sharing portaldesigndesigningdetermine efficacydevelopmentaldisease heterogeneitydisseminated lupus erythematosusdomestic dogefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationentire genomeevaluate efficacyexamine efficacyexomeexome sequencingexome-seqfull genomegene complementationgene networkgene repair therapygene therapygene-based therapygenetic conditiongenetic disordergenetic therapygenome mutationgenome scalegenome segmentgenome sequencinggenome-widegenomewidegenomic datagenomic datasetgenomic regiongenomic therapyglobal gene expressionglobal transcription profilehealth assessmenthistoriesinduced pluripotent stem cells derived from patientsinduced pluripotent stem cells from patientsinnovateinnovationinnovativeknockin miceleukemiamatememory T lymphocytemetabolism disordermouse modelmurine modelmyeloproliferative neoplasmnecropsyneuralneuronalob/ob mouseparentpatient derived human iPSpatient derived human iPSCpatient derived human induced pluripotent stem cellpatient derived iPSpatient derived iPSCpatient derived induced pluripotent cellspatient derived induced pluripotent stem cellspatient-derived pluripotent stem cellsperipheral bloodpostmortemprotein structure predictionpyruvate dehydrogenasescRNA sequencingscRNA-seqsex determinationsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsystemic lupus erythematosisthymus derived lymphocytetranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicsweb interfaceweb sitewebsitewhole genomexerodermosteosisyouth age
Description preview
The Bioinformatics and Scientific Programming Core actively supports the research being performed by NHGRI/DIR investigators by providing expertise and assistance in scientific programming and computational analysis. The Core facilitates access to specialized software and hardware, develops generalized software solutions that can address a variety…
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