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Next generation transcranial ultrasound-based neuromodulation using phase shift nanoemulsions

Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Feb 2023Deadline 23 Apr 2025 ⚠️
NIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAcousticsAminalonAminaloneAnesthestic DrugsAnesthetic AgentsAnesthetic DrugsAnestheticsAutomobile DrivingAutopsyBBB permeabilizationBBB permeableBRAIN initiativeBehavioralBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain Nervous SystemBrain Research through Advancing Innovative Neurotechnologies initiativeBrain regionCell BodyCellsCephalicCharacteristicsClinical TrialsCollaborationsCommon Rat StrainsComputer softwareContrast AgentContrast DrugsContrast MediaCranialDataDevelopmentDevicesDrug DeliveryDrug Delivery SystemsDrugsElementsEncephalonExcipientsExposure toFeedbackFocused UltrasoundFocused Ultrasound AblationFocused Ultrasound TherapyFocused Ultrasound TreatmentFormulationFunctional MRIFunctional Magnetic Resonance ImagingGABAGeneralized GrowthGoalsGrowthHemato-Encephalic BarrierHigh Power Focused UltrasoundHigh-intensity focused ultrasoundHumanImageInflammationInvestigatorsLaboratoriesLiquid substanceMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMapsMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMethodsMicrobubblesModalityModern ManMolecularMonitorMonkeysMsecNMR ImagingNMR TomographyNerve CellsNerve UnitNeural CellNeurocyteNeuronsNuclear Magnetic Resonance ImagingPatientsPentobarbital SodiumPharmaceutical PreparationsPhasePhysical condensationPhysiologic pulseProceduresPublishingPulseRadiopaque MediaRatRats MammalsRattusResearchResearch PersonnelResearchersRiskRodentRodentiaRodents MammalsSafetySchemeSkullSoftwareSpottingsSystemTechnologyTimeTissue GrowthTransducersTranslatingTranslationsUltrasonic TransducerUltrasound transducerWorkZeugmatographyblood oxygen level dependentblood oxygenation level dependentblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier permeabilizationbloodbrain barrier permeablecondensationcraniumdesigndesigningdevelop softwaredeveloping computer softwaredevelopmentaldrivingdrug/agentfMRIfluidgamma-Aminobutyric Acidimage guidanceimage guidedimagingimprovedliquidmillimetermillisecondmultidisciplinarynano emulsionnanoemulsionnecropsyneural controlneural imagingneural regulationneuro-imagingneuroimagingneurological imagingneuromodulationneuromodulatoryneuronalneuroregulationnext generationnon-human primatenonhuman primateontogenyopen sourceparticlepatient populationpharmacologicpostmortempressureputamenresponsesafety assessmentsensorimotor systemsensory motor systemside effectsoftware developmentsomatosensorytooltranslationtranslational modeltreatment planningultrasoundγ-Aminobutyric Acid

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Project Summary
This proposal responds to PAR-22-039 and aims to develop focused ultrasound (FUS) as a next
generation high precision device-based pharmacological neuromodulation tool and evaluate its use in non-
human primates as a translational step to humans. Current device-based neuromodulation technologies rely
on interaction with cells’…

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